SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ef1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 4 GLU A 238
MET A 292
LEU A 165
SER A 166
 None
 1.45A 1ee2B-3ef1A:
2.7		 1ee2B-3ef1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 264
ILE A 241
LEU A 230
VAL A 169
 None
None
None
BFD  A 170 ( 3.0A)
 0.90A 1fslB-3ef1A:
undetectable		 1fslB-3ef1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 439
PRO A 417
HIS A 177
GLU A 316
 None
 1.04A 1jtvA-3ef1A:
3.3		 1jtvA-3ef1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 282
ILE A 168
LEU A 167
SER A 166
 None
 0.93A 2byoA-3ef1A:
undetectable		 2byoA-3ef1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO A 211
ASN A 402
ARG A 271
 None
 0.98A 2qeuB-3ef1A:
undetectable		 2qeuB-3ef1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 GLN A 265
PHE A 264
LEU A 285
PHE A 286
 None
 1.30A 3ablC-3ef1A:
undetectable
3ablJ-3ef1A:
undetectable		 3ablC-3ef1A:
18.95
3ablJ-3ef1A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 453
ILE A 233
VAL A 169
ILE A 257
PHE A 229
 None
None
BFD  A 170 ( 3.0A)
None
None
 1.13A 3b2rA-3ef1A:
undetectable		 3b2rA-3ef1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 453
ILE A 233
VAL A 169
ILE A 257
PHE A 229
 None
None
BFD  A 170 ( 3.0A)
None
None
 1.10A 3b2rB-3ef1A:
undetectable		 3b2rB-3ef1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.74A 3ko0B-3ef1A:
undetectable		 3ko0B-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.70A 3ko0S-3ef1A:
undetectable		 3ko0S-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 PRO A 417
LEU A 438
LEU A 439
ILE A 321
 None
 0.98A 3u5jA-3ef1A:
undetectable		 3u5jA-3ef1A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 417
LEU A 438
LEU A 439
ILE A 321
 None
 0.89A 3u5kA-3ef1A:
undetectable		 3u5kA-3ef1A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A 271
THR A 246
ASP A 272
GLU A 209
 None
 1.40A 3v5vC-3ef1A:
undetectable
3v5vD-3ef1A:
undetectable		 3v5vC-3ef1A:
22.11
3v5vD-3ef1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 GLU A 209
ARG A 271
THR A 246
ASP A 272
 None
 1.42A 4e7cA-3ef1A:
undetectable
4e7cB-3ef1A:
undetectable		 4e7cA-3ef1A:
22.11
4e7cB-3ef1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 326
GLU A 404
VAL A 302
ARG A 299
 None
 1.03A 4lnwA-3ef1A:
undetectable		 4lnwA-3ef1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 491
LEU A 496
ALA A 517
LEU A 566
VAL A 557
 None
 1.10A 4p65C-3ef1A:
undetectable
4p65D-3ef1A:
undetectable
4p65J-3ef1A:
undetectable
4p65L-3ef1A:
undetectable		 4p65C-3ef1A:
6.28
4p65D-3ef1A:
4.56
4p65J-3ef1A:
4.56
4p65L-3ef1A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 580
ILE A 554
VAL A 545
ALA A 548
 None
 0.91A 5cu6A-3ef1A:
undetectable		 5cu6A-3ef1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
BFD  A 170 (-4.2A)
 1.41A 5vcvA-3ef1A:
undetectable		 5vcvA-3ef1A:
20.54