SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ef8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3ef8 PUTATIVE SCYALONE
DEHYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 5 THR A  58
THR A  69
HIS A  71
HIS A 138
 None
 1.49A 1d4fA-3ef8A:
undetectable		 1d4fA-3ef8A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3ef8 PUTATIVE SCYALONE
DEHYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 7 THR A  64
PHE A  66
THR A  99
ARG A  67
 None
 1.17A 2kotA-3ef8A:
undetectable		 2kotA-3ef8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3ef8 PUTATIVE SCYALONE
DEHYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 12 ASP A  24
HIS A 138
HIS A  96
PHE A  66
HIS A  71
 None
 1.47A 4bz6A-3ef8A:
undetectable
4bz6B-3ef8A:
undetectable		 4bz6A-3ef8A:
16.63
4bz6B-3ef8A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3ef8 PUTATIVE SCYALONE
DEHYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 11 ASN A  73
HIS A  71
HIS A  96
VAL A  92
LEU A 129
 None
 1.45A 4ygfA-3ef8A:
undetectable		 4ygfA-3ef8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ef8 PUTATIVE SCYALONE
DEHYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 8 TYR A  55
PHE A  47
LEU A  23
LEU A  31
 None
 0.80A 5hs1A-3ef8A:
undetectable		 5hs1A-3ef8A:
14.64