SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3efb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.98A 1cqeA-3efbA:
undetectable		 1cqeA-3efbA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.99A 1cqeB-3efbA:
undetectable		 1cqeB-3efbA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 11 ILE A 201
SER A 164
GLY A 192
ASN A 186
GLY A 240
 None
 1.31A 1ho5A-3efbA:
undetectable		 1ho5A-3efbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 11 PHE A 176
ASN A 209
ASP A 183
GLY A 179
ALA A 187
 None
 1.18A 1ju6A-3efbA:
undetectable		 1ju6A-3efbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		3 / 3 ASP A  61
LEU A  56
LEU A  57
 None
 0.80A 1np1B-3efbA:
undetectable		 1np1B-3efbA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 ALA A 232
ILE A 231
ILE A 162
LEU A 100
ILE A  93
 None
 1.11A 1xozA-3efbA:
undetectable		 1xozA-3efbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.94A 2aylB-3efbA:
undetectable		 2aylB-3efbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 MET A  45
LEU A  42
ILE A 241
ALA A  70
THR A 259
 None
 1.19A 2japA-3efbA:
undetectable		 2japA-3efbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 MET A  45
LEU A  42
ILE A 241
ALA A  70
THR A 259
 None
 1.20A 2japC-3efbA:
undetectable		 2japC-3efbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		3 / 3 ILE A 194
ILE A 217
LEU A 185
 None
 0.54A 2prgA-3efbA:
undetectable		 2prgA-3efbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		6 / 12 LEU A  57
ASP A  27
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.45A 2q63A-3efbA:
undetectable		 2q63A-3efbA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 LEU A  57
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.06A 2r5qA-3efbA:
undetectable		 2r5qA-3efbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 LEU A  57
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.06A 2r5qC-3efbA:
undetectable		 2r5qC-3efbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 7 ILE A 242
GLY A 243
PHE A 199
ILE A 162
 None
 0.75A 2y7wC-3efbA:
undetectable		 2y7wC-3efbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 ASP A  27
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.15A 3ekyB-3efbA:
undetectable		 3ekyB-3efbA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 6 PHE A 176
ASP A 193
TYR A 177
PRO A  96
 None
 1.42A 3jqaA-3efbA:
undetectable		 3jqaA-3efbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 8 GLY A 247
PHE A 199
ILE A 217
CYH A 195
 None
 0.89A 3ko0O-3efbA:
undetectable
3ko0Q-3efbA:
undetectable		 3ko0O-3efbA:
19.17
3ko0Q-3efbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.96A 3n8wA-3efbA:
undetectable		 3n8wA-3efbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 7 GLY A  94
GLY A  95
LEU A 100
PHE A 176
 None
 0.70A 3o9mA-3efbA:
undetectable		 3o9mA-3efbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.95A 3pghC-3efbA:
undetectable		 3pghC-3efbA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.95A 3pghD-3efbA:
undetectable		 3pghD-3efbA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		6 / 12 LEU A  57
ASP A  27
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.46A 4jecA-3efbA:
undetectable		 4jecA-3efbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 LEU A 129
ILE A  93
MET A 219
GLU A 218
ILE A 217
 None
 1.07A 4ltwA-3efbA:
undetectable		 4ltwA-3efbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 5 LEU A 263
SER A 258
LEU A  15
LEU A 253
 None
 1.24A 4n09B-3efbA:
4.1		 4n09B-3efbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 5 LEU A 263
SER A 258
LEU A  15
LEU A 253
 None
 1.22A 4n09D-3efbA:
3.8		 4n09D-3efbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		4 / 7 LEU A  47
ILE A 229
ILE A 231
VAL A 254
 None
 0.78A 4ojbA-3efbA:
undetectable		 4ojbA-3efbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.93A 4rs0A-3efbA:
undetectable		 4rs0A-3efbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 ALA A 128
SER A 216
GLY A  68
PHE A 176
GLY A 163
 None
 1.25A 4uilH-3efbA:
undetectable
4uilL-3efbA:
undetectable		 4uilH-3efbA:
21.65
4uilL-3efbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 ILE A 217
PHE A  65
GLY A  94
ALA A 113
LEU A  53
 None
 1.04A 5e72A-3efbA:
undetectable		 5e72A-3efbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 11 PHE A 176
ASN A 209
ASP A 183
GLY A 179
ALA A 187
 None
 1.22A 5fctA-3efbA:
undetectable		 5fctA-3efbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 10 ASP A  27
ALA A 158
ILE A 157
TYR A 227
GLY A  49
 None
 1.24A 5i6xA-3efbA:
undetectable		 5i6xA-3efbA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 12 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.96A 5ikrB-3efbA:
undetectable		 5ikrB-3efbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 LEU A  57
GLY A 230
ILE A 231
VAL A  63
ILE A 157
 None
 1.13A 5kr2D-3efbA:
undetectable		 5kr2D-3efbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3efb PROBABLE SOR-OPERON
REGULATOR
(Shigella
flexneri) 		5 / 9 GLY A 192
TYR A 177
VAL A 190
GLY A 163
PRO A 165
 None
 1.08A 5zniA-3efbA:
undetectable		 5zniA-3efbA:
13.53