SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3efm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.92A 1rxcB-3efmA:
undetectable		 1rxcB-3efmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.95A 1rxcE-3efmA:
undetectable		 1rxcE-3efmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.93A 1rxcI-3efmA:
undetectable		 1rxcI-3efmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.89A 1rxcK-3efmA:
undetectable		 1rxcK-3efmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 9 GLY A 536
SER A 538
VAL A  57
ILE A 132
VAL A 150
 None
 0.93A 2nnhB-3efmA:
undetectable		 2nnhB-3efmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 SER A 464
THR A 441
THR A  50
VAL A 133
ALA A 149
 None
 1.27A 2nniA-3efmA:
undetectable		 2nniA-3efmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ASP A 271
ASP A  24
ARG A 156
ASP A 105
HIS A 129
 None
 1.38A 2qmjA-3efmA:
undetectable		 2qmjA-3efmA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 TYR A 564
ALA A  31
ALA A  75
ALA A  72
THR A  68
 None
 0.98A 2x2nA-3efmA:
undetectable		 2x2nA-3efmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 TYR A 564
ALA A  75
ALA A  72
THR A  68
MET A 603
 None
 1.39A 2x2nD-3efmA:
undetectable		 2x2nD-3efmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		3 / 3 GLU A 264
ASP A 290
TYR A 268
 None
 0.81A 2yvlB-3efmA:
undetectable		 2yvlB-3efmA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		3 / 3 ASN A 339
TRP A 115
ASP A 311
 None
 1.21A 4a7tA-3efmA:
undetectable
4a7tF-3efmA:
undetectable		 4a7tA-3efmA:
11.72
4a7tF-3efmA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.95A 4e1vA-3efmA:
undetectable		 4e1vA-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.95A 4e1vC-3efmA:
undetectable		 4e1vC-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.95A 4e1vD-3efmA:
undetectable		 4e1vD-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.97A 4e1vE-3efmA:
undetectable		 4e1vE-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 1.00A 4e1vG-3efmA:
undetectable		 4e1vG-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 8 THR A  41
GLY A 395
ILE A 393
VAL A 394
 None
 0.98A 4e1vH-3efmA:
undetectable		 4e1vH-3efmA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 7 ILE A 111
THR A 120
PHE A 104
ASP A 311
 None
 1.34A 4iarA-3efmA:
undetectable		 4iarA-3efmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 4 ASN A 116
GLY A 118
ASP A 203
ASP A  69
 None
 1.38A 4n49A-3efmA:
undetectable		 4n49A-3efmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 6 LYS A 417
TYR A 414
ARG A 450
ALA A 449
 None
 1.25A 4o79B-3efmA:
undetectable		 4o79B-3efmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 6 LYS A 417
TYR A 414
ARG A 450
ALA A 449
 None
 1.47A 4o7gB-3efmA:
undetectable		 4o7gB-3efmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		3 / 3 PRO A  78
VAL A 130
HIS A 129
 None
 0.75A 4pevC-3efmA:
undetectable		 4pevC-3efmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 11 THR A 421
GLN A 445
GLY A 138
THR A 137
ALA A 136
 None
 1.25A 4qw0H-3efmA:
undetectable
4qw0I-3efmA:
undetectable		 4qw0H-3efmA:
16.76
4qw0I-3efmA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 11 THR A 421
GLN A 445
GLY A 138
THR A 137
ALA A 136
 None
 1.25A 4qw0V-3efmA:
undetectable
4qw0W-3efmA:
undetectable		 4qw0V-3efmA:
16.76
4qw0W-3efmA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ALA A 483
GLY A 520
ALA A 148
GLY A 135
PHE A 485
 None
 1.18A 4r29A-3efmA:
undetectable		 4r29A-3efmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ALA A 483
GLY A 520
ALA A 148
GLY A 135
PHE A 485
 None
 1.20A 4r29B-3efmA:
undetectable		 4r29B-3efmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 10 GLY A  71
ASN A 116
ALA A 148
ILE A  80
LEU A  74
 None
 1.14A 4xj7A-3efmA:
undetectable
4xj7B-3efmA:
undetectable		 4xj7A-3efmA:
17.51
4xj7B-3efmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 10 LEU A  74
GLY A  71
ASN A 116
ALA A 148
ILE A  80
 None
 1.17A 4xj7C-3efmA:
undetectable
4xj7D-3efmA:
undetectable		 4xj7C-3efmA:
17.51
4xj7D-3efmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 4 VAL A 133
ALA A 149
ASN A 101
GLN A 103
 None
 1.31A 4zgfA-3efmA:
undetectable		 4zgfA-3efmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 VAL A 219
LEU A 158
SER A 221
LEU A  25
THR A  26
 None
 1.34A 5hnxB-3efmA:
undetectable		 5hnxB-3efmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ILE A  80
GLY A  79
ASP A 522
ALA A  77
VAL A  57
 None
 1.19A 5hw4A-3efmA:
undetectable		 5hw4A-3efmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 11 ILE A  80
GLY A  79
ASP A 522
ALA A  77
VAL A  57
 None
 1.25A 5hw4B-3efmA:
undetectable		 5hw4B-3efmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ILE A  80
GLY A  79
ASP A 522
ALA A  77
VAL A  57
 None
 1.21A 5hw4C-3efmA:
undetectable		 5hw4C-3efmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 5 ASP A 180
THR A 164
ARG A 649
GLU A  27
 None
 1.19A 5k9dA-3efmA:
undetectable		 5k9dA-3efmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ASP A 271
ASP A  24
ARG A 156
ASP A 105
HIS A 129
 None
 1.36A 5nn8A-3efmA:
undetectable		 5nn8A-3efmA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		5 / 12 ALA A 537
GLY A 536
SER A 526
GLN A  60
GLU A  63
 None
 1.21A 5nwuA-3efmA:
undetectable		 5nwuA-3efmA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		3 / 3 GLY A 118
ASN A 116
ARG A 310
 None
 0.71A 5w7bD-3efmA:
undetectable		 5w7bD-3efmA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR
(Bordetella
pertussis) 		4 / 7 SER A 318
SER A 316
HIS A 314
GLY A 333
 None
 1.11A 6btxA-3efmA:
undetectable		 6btxA-3efmA:
22.28