SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3efy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		3 / 3 ASP A 187
ASP A 160
ASP A 237
 None
 0.74A 2igtA-3efyA:
undetectable		 2igtA-3efyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		3 / 3 ASP A 187
ASP A 160
ASP A 237
 None
 0.72A 2igtB-3efyA:
undetectable		 2igtB-3efyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		4 / 7 LEU A 141
LEU A 138
LEU A 156
TYR A 167
 None
 0.85A 2vq5B-3efyA:
undetectable		 2vq5B-3efyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		4 / 7 LEU A 141
LEU A 138
PHE A 260
TYR A 167
 None
 0.95A 2vq5B-3efyA:
undetectable		 2vq5B-3efyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		3 / 3 PHE A 260
TYR A 218
TYR A 167
 None
 0.90A 4ffwA-3efyA:
undetectable		 4ffwA-3efyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		4 / 6 PHE A 260
VAL A 158
TYR A 167
ILE A 215
 None
 0.94A 5iwuA-3efyA:
undetectable		 5iwuA-3efyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		4 / 5 GLY A 240
ASN A 241
ASP A 239
ARG A 194
 None
 1.37A 6dwdB-3efyA:
undetectable
6dwdD-3efyA:
undetectable		 6dwdB-3efyA:
16.04
6dwdD-3efyA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3efy CIF (CELL CYCLE
INHIBITING FACTOR)
(Escherichia
coli) 		4 / 5 ARG A 194
GLY A 240
ASN A 241
ASP A 239
 None
 1.36A 6dwjB-3efyA:
undetectable
6dwjD-3efyA:
undetectable		 6dwjB-3efyA:
16.04
6dwjD-3efyA:
16.04