SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3efz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		3 / 3 ASP A 150
ARG A 153
ILE A 204
 SEP  A 265 ( 4.9A)
SEP  A 265 ( 2.9A)
SEP  A 265 ( 4.6A)
 0.82A 1a4gB-3efzA:
undetectable		 1a4gB-3efzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		4 / 8 GLU A 157
ARG A  79
LEU A 209
LEU A 263
 None
SEP  A 265 ( 3.2A)
None
None
 0.96A 1cmaA-3efzA:
undetectable
1cmaB-3efzA:
undetectable		 1cmaA-3efzA:
19.46
1cmaB-3efzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		4 / 8 TYR A 154
LEU A 151
LEU A 159
GLU A 120
 SEP  A 265 ( 4.6A)
None
None
None
 0.92A 1i7zA-3efzA:
undetectable		 1i7zA-3efzA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		4 / 6 TYR A 202
TYR A 195
PHE A 268
LEU A 244
 None
 0.96A 2w98A-3efzA:
undetectable
2w98B-3efzA:
undetectable		 2w98A-3efzA:
22.49
2w98B-3efzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		4 / 7 LYS A 148
LEU A 132
ASP A 129
SER A 136
 EDO  A 305 ( 4.0A)
None
EDO  A 305 (-3.4A)
None
 1.45A 3dzgA-3efzA:
undetectable		 3dzgA-3efzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		3 / 3 ASN A 212
LEU A 263
PHE A 219
 None
 0.74A 4dajB-3efzA:
1.9		 4dajB-3efzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		4 / 5 LEU A 196
ARG A 231
ARG A 249
THR A 203
 None
 1.47A 4p3qA-3efzA:
undetectable		 4p3qA-3efzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		5 / 9 ARG A  72
ALA A 266
PHE A 267
PRO A 193
LEU A 244
 None
SEP  A 265 ( 3.7A)
None
None
None
 1.44A 5i73A-3efzA:
5.4		 5i73A-3efzA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3efz 14-3-3 PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A 178
ALA A 142
PHE A 143
PHE A 185
LEU A 186
 None
 1.14A 5k9dA-3efzA:
undetectable		 5k9dA-3efzA:
20.80