SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		3 / 3 PHE B 364
LEU B 371
SER B 430
 None
 0.94A 1e7aA-3eg5B:
2.2		 1e7aA-3eg5B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 7 GLU B 230
LEU B 233
GLU B 276
MET B 280
 None
 0.99A 1linA-3eg5B:
undetectable		 1linA-3eg5B:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 1v54A-3eg5B:
undetectable
1v54J-3eg5B:
undetectable		 1v54A-3eg5B:
19.00
1v54J-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 2dyrA-3eg5B:
undetectable
2dyrJ-3eg5B:
undetectable		 2dyrA-3eg5B:
19.00
2dyrJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 2dysA-3eg5B:
undetectable
2dysJ-3eg5B:
undetectable		 2dysA-3eg5B:
19.00
2dysJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 2dysN-3eg5B:
undetectable
2dysW-3eg5B:
undetectable		 2dysN-3eg5B:
19.00
2dysW-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.05A 2eijA-3eg5B:
undetectable
2eijJ-3eg5B:
undetectable		 2eijA-3eg5B:
19.00
2eijJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.04A 2eilA-3eg5B:
undetectable
2eilJ-3eg5B:
undetectable		 2eilA-3eg5B:
19.00
2eilJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR B 297
ASP B 240
SER B 202
 None
 0.77A 2nxeA-3eg5B:
undetectable		 2nxeA-3eg5B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR B 297
ASP B 240
SER B 202
 None
 0.78A 2nxeB-3eg5B:
undetectable		 2nxeB-3eg5B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.02A 3abmA-3eg5B:
undetectable
3abmJ-3eg5B:
undetectable		 3abmA-3eg5B:
19.00
3abmJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.04A 3asnA-3eg5B:
undetectable
3asnJ-3eg5B:
undetectable		 3asnA-3eg5B:
19.00
3asnJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 3asoA-3eg5B:
undetectable
3asoJ-3eg5B:
undetectable		 3asoA-3eg5B:
19.00
3asoJ-3eg5B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 251
ILE B 248
THR B 297
SER B 298
LEU B 341
 None
 1.04A 3cl9A-3eg5B:
undetectable		 3cl9A-3eg5B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 12 MET B 266
ALA B 273
GLU B 276
LEU B 233
LEU B 254
 None
 1.15A 3hm1A-3eg5B:
undetectable		 3hm1A-3eg5B:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		3 / 3 ARG B 326
HIS B 435
SER B 327
 None
 1.03A 4mjwA-3eg5B:
undetectable
4mjwB-3eg5B:
undetectable		 4mjwA-3eg5B:
21.04
4mjwB-3eg5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		3 / 3 SER B 327
ARG B 326
HIS B 435
 None
 1.00A 4mjwA-3eg5B:
undetectable
4mjwB-3eg5B:
undetectable		 4mjwA-3eg5B:
21.04
4mjwB-3eg5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.15A 4q0dA-3eg5B:
undetectable		 4q0dA-3eg5B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.15A 4q0dB-3eg5B:
undetectable		 4q0dB-3eg5B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.15A 4q0dE-3eg5B:
undetectable		 4q0dE-3eg5B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1
(Mus
musculus) 		5 / 10 ALA B 278
VAL B 236
LEU B 308
LEU B 289
PHE B 286
 None
 1.27A 4zmeB-3eg5B:
undetectable		 4zmeB-3eg5B:
22.44