SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3egc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 4 HIS A 184
LEU A 240
LEU A 264
LEU A 289
 None
 1.04A 1a4lD-3egcA:
undetectable		 1a4lD-3egcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 VAL A 275
ILE A 190
GLY A 259
ALA A 260
LEU A 264
 None
 0.90A 1eqhA-3egcA:
undetectable		 1eqhA-3egcA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 VAL A 275
ILE A 190
GLY A 259
ALA A 260
LEU A 264
 None
 0.89A 1eqhB-3egcA:
undetectable		 1eqhB-3egcA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 8 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.89A 1gsfA-3egcA:
undetectable		 1gsfA-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 8 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.90A 1gsfB-3egcA:
undetectable		 1gsfB-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 8 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.89A 1gsfC-3egcA:
undetectable		 1gsfC-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 8 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.89A 1gsfD-3egcA:
undetectable		 1gsfD-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 MET A 261
LEU A 264
ASN A 265
LEU A 267
GLY A 268
 None
 1.17A 1p93A-3egcA:
undetectable		 1p93A-3egcA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 MET A 261
LEU A 264
ASN A 265
LEU A 269
GLY A 268
 None
 1.28A 1p93A-3egcA:
undetectable		 1p93A-3egcA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 GLU A 135
GLU A 112
LEU A 143
 None
 0.73A 1v8bA-3egcA:
5.5		 1v8bA-3egcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 7 GLY A 259
ALA A 260
MET A 261
LEU A 264
 None
 0.54A 2wekB-3egcA:
undetectable		 2wekB-3egcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 SER A 279
GLU A 258
ASP A 281
 None
 0.75A 2zthA-3egcA:
4.8		 2zthA-3egcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 SER A 279
GLU A 258
ASP A 281
 None
 0.83A 3bwmA-3egcA:
4.9		 3bwmA-3egcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 SER A 279
GLU A 258
ASP A 281
 None
 0.77A 3bwyA-3egcA:
5.2		 3bwyA-3egcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 ARG A 325
GLY A 162
LEU A 311
GLU A 155
ALA A 151
 None
 1.26A 3sxjA-3egcA:
3.5		 3sxjA-3egcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 ARG A 325
GLY A 162
LEU A 311
GLU A 155
ALA A 151
 None
 1.28A 3sxjB-3egcA:
undetectable		 3sxjB-3egcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 8 ILE A  77
LEU A 102
VAL A  89
GLY A  88
 None
 0.89A 3w1wA-3egcA:
5.3		 3w1wA-3egcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 5 GLU A 135
GLY A 134
TYR A 138
GLU A 112
 None
 1.45A 3w9tA-3egcA:
undetectable		 3w9tA-3egcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 5 GLU A 135
GLY A 134
TYR A 138
GLU A 112
 None
 1.45A 3w9tC-3egcA:
undetectable		 3w9tC-3egcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 5 GLU A 135
GLY A 134
TYR A 138
GLU A 112
 None
 1.45A 3w9tD-3egcA:
undetectable		 3w9tD-3egcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		4 / 5 GLU A 135
GLY A 134
TYR A 138
GLU A 112
 None
 1.44A 3w9tG-3egcA:
undetectable		 3w9tG-3egcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 PHE A  81
VAL A 152
ILE A 128
GLU A 107
VAL A  89
 None
 1.33A 4a97B-3egcA:
undetectable
4a97C-3egcA:
undetectable		 4a97B-3egcA:
21.60
4a97C-3egcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 GLU A 276
ARG A 182
HIS A 184
 None
 0.86A 4kf9A-3egcA:
undetectable		 4kf9A-3egcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 GLY A 259
ALA A 260
LEU A 264
LEU A 267
LEU A 269
 None
 0.91A 4o1zA-3egcA:
undetectable		 4o1zA-3egcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 ASN A 153
PHE A  81
ARG A 202
VAL A 164
ARG A 325
 None
 1.44A 4po0A-3egcA:
undetectable		 4po0A-3egcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 SER A 279
GLU A 258
ASP A 281
 None
 0.84A 4xudA-3egcA:
5.0		 4xudA-3egcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		3 / 3 ASN A 104
ALA A 106
ARG A 111
 None
 0.77A 5cvtB-3egcA:
10.5		 5cvtB-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3egc PUTATIVE RIBOSE
OPERON REPRESSOR
(Burkholderia
thailandensis) 		5 / 12 GLN A 298
VAL A 152
GLY A  88
ALA A  86
LEU A  72
 None
 1.11A 5kirB-3egcA:
undetectable		 5kirB-3egcA:
18.33