SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3egh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3egh SPINOPHILIN
(Rattus
norvegicus) 		5 / 11 LEU C 506
GLY C 507
ILE C 508
SER C 509
ILE C 510
 None
 0.58A 2kawA-3eghC:
12.7		 2kawA-3eghC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3egh SPINOPHILIN
(Rattus
norvegicus) 		4 / 7 LEU C 557
VAL C 560
VAL C 568
LEU C 521
 None
 0.95A 3rgfA-3eghC:
undetectable		 3rgfA-3eghC:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3egh SPINOPHILIN
(Rattus
norvegicus) 		5 / 12 ILE C 510
VAL C 528
LEU C 549
ALA C 537
LEU C 506
 None
 1.12A 4m11D-3eghC:
undetectable		 4m11D-3eghC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3egh SPINOPHILIN
(Rattus
norvegicus) 		3 / 3 ILE C 434
PRO C 435
ILE C 456
 None
 0.42A 5hw8F-3eghC:
undetectable		 5hw8F-3eghC:
24.40