SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3egi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 700
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 ADP  A   3 (-3.5A)
ADP  A   3 (-3.8A)
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.48A 1qaoA-3egiA:
11.4		 1qaoA-3egiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		6 / 12 GLY A 702
GLY A 703
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 None
None
ADP  A   3 (-3.8A)
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.63A 1sqfA-3egiA:
12.7		 1sqfA-3egiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 ALA A 682
THR A 711
PHE A 761
 None
 0.72A 2c6nB-3egiA:
undetectable		 2c6nB-3egiA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
GLY A 702
ASP A 747
PRO A 765
 ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.98A 2dpmA-3egiA:
11.1		 2dpmA-3egiA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 700
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 ADP  A   3 (-3.5A)
None
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.69A 2hmyB-3egiA:
8.5		 2hmyB-3egiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
GLY A 703
ASP A 721
PRO A 765
 ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
None
None
ADP  A   3 (-3.3A)
 0.48A 2hmyB-3egiA:
8.5		 2hmyB-3egiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 6 SER A 816
LEU A 817
ASP A 810
ASP A 812
 None
 1.18A 2j2pE-3egiA:
undetectable
2j2pF-3egiA:
undetectable		 2j2pE-3egiA:
23.63
2j2pF-3egiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 7 ARG A 848
GLU A 825
GLU A 827
SER A 656
 None
 1.10A 2zt7A-3egiA:
undetectable		 2zt7A-3egiA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 SER A 688
GLU A 827
ASP A 660
 None
 0.65A 2zulA-3egiA:
11.8		 2zulA-3egiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 10 PHE A 698
GLY A 700
ASP A 719
ILE A 720
ASP A 747
 ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.8A)
ADP  A   3 (-3.4A)
 0.34A 3ay0B-3egiA:
6.5		 3ay0B-3egiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 ASN A 829
PHE A 761
ALA A 682
VAL A 814
ILE A 838
 None
 1.00A 3czhB-3egiA:
undetectable		 3czhB-3egiA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 SER A 688
GLU A 827
ASP A 660
 None
 0.67A 3dmhA-3egiA:
11.7		 3dmhA-3egiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 ADP  A   3 (-4.5A)
None
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.53A 3eeoA-3egiA:
9.5		 3eeoA-3egiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 LYS A 796
ARG A 792
ASP A 747
 None
None
ADP  A   3 (-3.4A)
 1.46A 3o7wA-3egiA:
9.0		 3o7wA-3egiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 GLY A 700
ASP A 719
ASP A 747
 ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.4A)
 0.34A 3ou7C-3egiA:
11.6		 3ou7C-3egiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 THR A 839
VAL A 802
GLU A 825
 None
 0.78A 3v4tA-3egiA:
undetectable
3v4tD-3egiA:
1.9		 3v4tA-3egiA:
20.77
3v4tD-3egiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 700
ASP A 719
ASP A 721
ASP A 747
PRO A 765
 ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.59A 3v8vB-3egiA:
14.6		 3v8vB-3egiA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 685
PHE A 761
PHE A 708
ASN A 704
TYR A 841
 None
 1.50A 4amjA-3egiA:
undetectable		 4amjA-3egiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 LEU A 805
PRO A 806
ARG A 653
 None
 0.73A 4klrB-3egiA:
undetectable		 4klrB-3egiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 6 ARG A 848
GLU A 825
GLU A 827
SER A 656
 None
 1.07A 4kr3A-3egiA:
undetectable		 4kr3A-3egiA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 7 TYR A 803
VAL A 824
ILE A 826
ILE A 811
ALA A 809
 None
 1.48A 4lv9A-3egiA:
undetectable		 4lv9A-3egiA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 7 ILE A 790
PHE A 698
LEU A 749
ASP A 747
 None
ADP  A   3 (-4.5A)
None
ADP  A   3 (-3.4A)
 1.07A 4mmcA-3egiA:
undetectable		 4mmcA-3egiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
ASP A 719
ILE A 720
PRO A 765
 ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.8A)
ADP  A   3 (-3.3A)
 0.44A 4rtsA-3egiA:
11.5		 4rtsA-3egiA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 4 ASP A 696
GLY A 700
ASP A 719
ASP A 747
 None
ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.4A)
 0.44A 5e72A-3egiA:
15.7		 5e72A-3egiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 PHE A 698
GLY A 700
ILE A 720
ASP A 747
PRO A 765
 ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
ADP  A   3 (-3.8A)
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.61A 5hjiA-3egiA:
14.7		 5hjiA-3egiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 10 ALA A 732
ILE A 706
GLY A 712
GLY A 736
VAL A 715
 None
 1.12A 5i6xA-3egiA:
undetectable		 5i6xA-3egiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 718
VAL A 715
LEU A 845
THR A 839
TYR A 803
 None
 1.31A 5igpA-3egiA:
undetectable		 5igpA-3egiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 839
ASN A 704
PHE A 708
TYR A 841
 None
 1.30A 5v4vA-3egiA:
undetectable		 5v4vA-3egiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 839
ASN A 704
PHE A 708
TYR A 841
 None
 1.29A 5v4vB-3egiA:
undetectable		 5v4vB-3egiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 6 GLN A 813
VAL A 814
ALA A 840
THR A 839
 None
 1.01A 6cduB-3egiA:
undetectable
6cduC-3egiA:
undetectable		 6cduB-3egiA:
19.14
6cduC-3egiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 787
LEU A 749
ALA A 752
SER A 794
ALA A 697
 None
 1.27A 6qgbA-3egiA:
undetectable		 6qgbA-3egiA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 787
LEU A 749
ALA A 752
SER A 794
ALA A 697
 None
 1.27A 6qgbE-3egiA:
undetectable		 6qgbE-3egiA:
16.07