SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3egl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 ILE A 240
PHE A 171
SER A 149
ILE A 146
LEU A 140
 PLM  A 275 ( 4.4A)
None
MLY  A 148 ( 4.2A)
None
None
 1.21A 1dlsA-3eglA:
undetectable		 1dlsA-3eglA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		6 / 12 ILE A 240
LEU A  72
PHE A 171
SER A 149
ILE A 146
LEU A 140
 PLM  A 275 ( 4.4A)
PLM  A 275 ( 4.2A)
None
MLY  A 148 ( 4.2A)
None
None
 1.26A 1drfA-3eglA:
undetectable		 1drfA-3eglA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 11 LEU A  66
GLY A 100
ALA A  11
VAL A  25
VAL A   5
 None
PLM  A 275 ( 4.2A)
None
None
None
 0.95A 1hxwB-3eglA:
undetectable		 1hxwB-3eglA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 6 ALA A  11
LEU A  99
ILE A  68
SER A   9
 None
PLM  A 275 ( 4.6A)
None
None
 1.07A 1sbrA-3eglA:
undetectable
1sbrB-3eglA:
undetectable		 1sbrA-3eglA:
22.46
1sbrB-3eglA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 5 LEU A 229
VAL A  17
LEU A  13
ARG A 112
 None
None
None
MLY  A 115 ( 4.4A)
 1.05A 2oiqA-3eglA:
undetectable		 2oiqA-3eglA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 11 LEU A 221
ILE A 168
PHE A 189
ALA A 188
GLU A 145
 None
None
None
MLY  A 187 ( 3.7A)
None
 1.20A 2v0mD-3eglA:
undetectable		 2v0mD-3eglA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 9 VAL A  25
ALA A  11
THR A  75
SER A  73
ILE A  26
 None
None
None
PLM  A 275 (-2.6A)
None
 1.35A 3hbbB-3eglA:
2.1		 3hbbB-3eglA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 LEU A 221
LEU A 192
LEU A 195
ILE A 209
VAL A 205
 None
MLY  A 191 ( 4.5A)
MLY  A 191 ( 3.7A)
None
None
 1.25A 4f4dB-3eglA:
2.5		 4f4dB-3eglA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 5 HIS A 141
ALA A 214
GLN A 185
TYR A 139
 None
 1.17A 4gboA-3eglA:
undetectable		 4gboA-3eglA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 5 HIS A 141
ALA A 214
GLN A 185
TYR A 139
 None
 1.07A 4gboB-3eglA:
undetectable		 4gboB-3eglA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 GLY A 104
GLY A 100
LEU A  13
PRO A  14
VAL A  17
 None
PLM  A 275 ( 4.2A)
None
None
None
 0.96A 4gc9A-3eglA:
undetectable		 4gc9A-3eglA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 10 LEU A 221
LEU A 192
LEU A 195
ILE A 209
VAL A 205
 None
MLY  A 191 ( 4.5A)
MLY  A 191 ( 3.7A)
None
None
 1.19A 4mk4A-3eglA:
undetectable		 4mk4A-3eglA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 8 ALA A 208
PHE A 206
ALA A 102
GLY A 104
MET A 108
 None
 1.03A 4zjzA-3eglA:
4.6		 4zjzA-3eglA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 8 ALA A 208
VAL A 238
ALA A 102
GLY A 100
 None
None
None
PLM  A 275 ( 4.2A)
 0.55A 4zjzA-3eglA:
4.6		 4zjzA-3eglA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 10 THR A  96
ALA A 106
GLY A 100
ALA A 105
HIS A  67
 None
None
PLM  A 275 ( 4.2A)
None
None
 1.20A 5eeuF-3eglA:
undetectable
5eeuG-3eglA:
undetectable		 5eeuF-3eglA:
13.98
5eeuG-3eglA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 5 HIS A 141
ALA A 214
GLN A 185
TYR A 139
 None
 1.18A 5uizA-3eglA:
undetectable		 5uizA-3eglA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 LEU A 163
ILE A 152
ILE A  68
LEU A  99
MET A 169
 None
None
None
PLM  A 275 ( 4.6A)
None
 1.02A 5y2tB-3eglA:
undetectable		 5y2tB-3eglA:
undetectable