SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ego'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.28A 1a52A-3egoA:
undetectable		 1a52A-3egoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.31A 1a52B-3egoA:
undetectable		 1a52B-3egoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.28A 1ereA-3egoA:
undetectable		 1ereA-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.28A 1ereB-3egoA:
undetectable		 1ereB-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 1ereC-3egoA:
undetectable		 1ereC-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.26A 1ereD-3egoA:
undetectable		 1ereD-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 8 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.27A 1ereE-3egoA:
undetectable		 1ereE-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 8 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.27A 1ereF-3egoA:
undetectable		 1ereF-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.34A 1gwrA-3egoA:
undetectable		 1gwrA-3egoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 1pcgA-3egoA:
undetectable		 1pcgA-3egoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.27A 1pcgB-3egoA:
undetectable		 1pcgB-3egoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.31A 1qkuA-3egoA:
undetectable		 1qkuA-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.32A 1qkuB-3egoA:
undetectable		 1qkuB-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.32A 1qkuC-3egoA:
undetectable		 1qkuC-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 7 ALA A  58
ASP A  59
GLY A   4
ILE A   3
 None
 0.91A 2fxdB-3egoA:
undetectable		 2fxdB-3egoA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 7 ILE A 115
GLN A  97
LEU A  78
LEU A  85
 None
 1.02A 2qqcB-3egoA:
undetectable
2qqcC-3egoA:
undetectable		 2qqcB-3egoA:
17.11
2qqcC-3egoA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 7 LEU A  78
LEU A  85
ILE A 115
GLN A  97
 None
 1.04A 2qqcA-3egoA:
undetectable
2qqcF-3egoA:
undetectable		 2qqcA-3egoA:
11.40
2qqcF-3egoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 7 LEU A  78
LEU A  85
ILE A 115
GLN A  97
 None
 1.02A 2qqcI-3egoA:
undetectable
2qqcL-3egoA:
undetectable		 2qqcI-3egoA:
11.40
2qqcL-3egoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 11 HIS A 161
LEU A  45
ALA A  54
ILE A  43
ILE A   3
 None
 1.16A 3b2rB-3egoA:
undetectable		 3b2rB-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		3 / 3 SER A  80
GLN A  79
PHE A  82
 None
 0.61A 3g4lC-3egoA:
undetectable		 3g4lC-3egoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 12 LEU A 106
VAL A 111
GLY A 112
ILE A  88
ILE A   6
 None
 1.12A 3ijdA-3egoA:
undetectable		 3ijdA-3egoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 12 LEU A 106
VAL A 111
GLY A 112
ILE A  88
ILE A   6
 None
 1.12A 3ijdB-3egoA:
undetectable		 3ijdB-3egoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ILE A  93
THR A  91
VAL A  71
ILE A   6
ILE A  62
 None
 1.13A 3kpbD-3egoA:
undetectable		 3kpbD-3egoA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		3 / 3 SER A  84
SER A  83
HIS A 113
 None
 0.82A 3mzeA-3egoA:
undetectable		 3mzeA-3egoA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 12 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 3olsB-3egoA:
undetectable		 3olsB-3egoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 3uudB-3egoA:
undetectable		 3uudB-3egoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 5 ALA A 148
ASN A  92
ARG A 152
PRO A 150
 None
 1.36A 3vxiA-3egoA:
0.0		 3vxiA-3egoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 5 GLY A 118
ILE A 166
LEU A  68
LEU A  78
 None
 0.85A 4o8fA-3egoA:
undetectable		 4o8fA-3egoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 184
GLN A 273
LEU A 266
LEU A 221
ARG A 219
 None
 1.24A 4x30A-3egoA:
undetectable		 4x30A-3egoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 5dxeB-3egoA:
undetectable		 5dxeB-3egoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 8 ILE A  38
GLY A   7
THR A  72
LEU A  19
 None
 0.82A 5hs1A-3egoA:
undetectable		 5hs1A-3egoA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.32A 5hyrA-3egoA:
undetectable		 5hyrA-3egoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 11 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.28A 5hyrB-3egoA:
undetectable		 5hyrB-3egoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ARG A 152
ILE A   6
GLY A   4
ILE A   3
ILE A  93
 None
 1.10A 5kqxB-3egoA:
undetectable		 5kqxB-3egoA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.32A 5wgdA-3egoA:
0.1		 5wgdA-3egoA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		5 / 10 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.26A 5wgqB-3egoA:
undetectable		 5wgqB-3egoA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE
(Bacillus
subtilis) 		4 / 8 ASP A 250
SER A 246
GLY A   7
ASN A  98
 None
 0.96A 6giqL-3egoA:
undetectable
6giqP-3egoA:
undetectable
6giqT-3egoA:
undetectable		 6giqL-3egoA:
20.57
6giqP-3egoA:
22.19
6giqT-3egoA:
12.63