SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 TYR A 730
LEU A 703
LEU A 704
HIS A 728
LEU A 696
 None
 1.40A 1fmlA-3eh1A:
undetectable		 1fmlA-3eh1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 11 ALA A 922
GLY A 805
GLY A 919
ILE A 954
VAL A 679
 None
 1.06A 1pg2A-3eh1A:
undetectable		 1pg2A-3eh1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 11 ALA A1023
ALA A1026
LEU A1042
ALA A1041
VAL A1078
 None
 1.05A 2bxeB-3eh1A:
undetectable		 2bxeB-3eh1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 10 ALA A1023
ALA A1026
LEU A1042
ALA A1041
VAL A1078
 None
 0.98A 2bxgB-3eh1A:
undetectable		 2bxgB-3eh1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 9 LEU A 776
LEU A 772
ILE A 769
PHE A 720
LEU A 703
 None
 1.26A 2f78A-3eh1A:
1.7		 2f78A-3eh1A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 9 LEU A 776
LEU A 772
ILE A 769
PHE A 720
LEU A 703
 None
 1.27A 2f78B-3eh1A:
undetectable		 2f78B-3eh1A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 THR A 845
ASP A 854
SER A 856
 None
 0.82A 2nxeA-3eh1A:
undetectable		 2nxeA-3eh1A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 THR A 845
ASP A 854
SER A 856
 None
 0.77A 2nxeB-3eh1A:
undetectable		 2nxeB-3eh1A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 GLY A 694
ALA A 693
LEU A 773
LEU A 776
LEU A 914
 None
 0.88A 2nyuA-3eh1A:
undetectable		 2nyuA-3eh1A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ASN A 953
MET A 801
LEU A 794
LEU A 681
PHE A 920
 None
 1.19A 2oaxB-3eh1A:
undetectable		 2oaxB-3eh1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ASN A1024
LEU A1022
ALA A1023
MET A1114
LEU A1110
 None
 1.41A 2oaxE-3eh1A:
undetectable		 2oaxE-3eh1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ASN A 953
MET A 801
LEU A 794
LEU A 681
PHE A 920
 None
 1.15A 2oaxF-3eh1A:
undetectable		 2oaxF-3eh1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ILE A 966
THR A 929
GLY A 931
LEU A 949
PHE A 937
 None
 1.01A 2y7hB-3eh1A:
undetectable		 2y7hB-3eh1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ILE A 966
THR A 929
GLY A 931
LEU A 949
PHE A 937
 None
 1.01A 2y7hC-3eh1A:
undetectable		 2y7hC-3eh1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 GLY A 959
ALA A1023
VAL A1111
HIS A1112
LEU A1113
 None
 1.01A 2yqzA-3eh1A:
undetectable		 2yqzA-3eh1A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 5 GLN A1084
ALA A1101
GLN A1104
ILE A1105
 None
 1.46A 2z0aA-3eh1A:
undetectable		 2z0aA-3eh1A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ALA A 885
PRO A 677
GLY A 805
THR A 804
VAL A 808
 None
 1.18A 2zifA-3eh1A:
undetectable		 2zifA-3eh1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 5 PRO A1075
THR A1056
VAL A1057
GLY A1054
 None
 1.11A 3elzA-3eh1A:
undetectable		 3elzA-3eh1A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 GLN A 858
GLY A 805
GLY A 857
GLU A 921
ALA A 952
 None
 1.07A 3kkzB-3eh1A:
undetectable		 3kkzB-3eh1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 8 PHE A1179
ALA A1158
LEU A1227
MET A1196
 None
 0.82A 3l4dA-3eh1A:
undetectable		 3l4dA-3eh1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 ASN A 532
GLU A 530
ARG A 531
 None
 0.90A 3wxoA-3eh1A:
1.0		 3wxoA-3eh1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 ARG A 925
TYR A 630
ASN A 633
 None
 0.56A 4ffwB-3eh1A:
undetectable		 4ffwB-3eh1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 LEU A1021
MET A1025
ASP A 947
 None
 0.80A 4j7xB-3eh1A:
undetectable		 4j7xB-3eh1A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 LEU A1021
ASN A1024
LEU A1022
ALA A1023
LEU A1110
 None
 1.11A 4ltwA-3eh1A:
undetectable		 4ltwA-3eh1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 VAL A1046
SER A1049
PHE A1258
LEU A 534
VAL A1015
 None
 1.22A 4nc3A-3eh1A:
undetectable		 4nc3A-3eh1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 LEU A1021
LEU A 964
THR A 946
ALA A 961
ILE A 926
 None
 0.99A 4o2bD-3eh1A:
3.0		 4o2bD-3eh1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 5 LEU A 914
ILE A 718
LEU A 773
LEU A 867
 None
 0.87A 4o8fA-3eh1A:
undetectable		 4o8fA-3eh1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 LEU A1021
LEU A 964
THR A 946
ALA A 961
ILE A 926
 None
 1.11A 4x1iD-3eh1A:
4.9		 4x1iD-3eh1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 PHE A 865
ILE A 718
LEU A 699
LEU A 910
LEU A 914
 None
 1.30A 4xumA-3eh1A:
undetectable		 4xumA-3eh1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 MET A1161
HIS A1243
GLY A1164
 None
 0.83A 5gwzB-3eh1A:
undetectable		 5gwzB-3eh1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 6 GLU A 663
ARG A 994
LEU A 982
ARG A 991
 None
 0.97A 5l6eA-3eh1A:
undetectable
5l6eB-3eh1A:
undetectable		 5l6eA-3eh1A:
16.12
5l6eB-3eh1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 8 TRP A 624
THR A 610
TYR A 611
THR A 997
 None
 1.33A 5tzoB-3eh1A:
undetectable		 5tzoB-3eh1A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		4 / 8 LEU A 584
VAL A 962
LEU A 998
ILE A 926
 None
 0.72A 5v0vA-3eh1A:
undetectable		 5v0vA-3eh1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		3 / 3 SER A1036
LYS A 836
SER A1034
 None
 0.59A 6az3P-3eh1A:
undetectable		 6az3P-3eh1A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ILE A1124
PHE A1179
GLY A1157
ILE A1229
LEU A1184
 None
 1.00A 6dwnC-3eh1A:
undetectable		 6dwnC-3eh1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ILE A1124
PHE A1179
GLY A1157
ILE A1229
LEU A1184
 None
 1.08A 6dwnD-3eh1A:
undetectable		 6dwnD-3eh1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens) 		5 / 12 ILE A1169
PHE A1179
GLY A1157
ASP A1176
ILE A1192
 None
 0.91A 6dwnD-3eh1A:
undetectable		 6dwnD-3eh1A:
8.88