SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 4 THR A 628
LEU A 627
LEU A 712
GLN A 715
 None
 1.10A 1fbmA-3eh2A:
undetectable		 1fbmA-3eh2A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 THR A 487
ASP A 423
ALA A 424
GLY A 310
GLY A 364
 None
 1.08A 1rjdA-3eh2A:
undetectable		 1rjdA-3eh2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 THR A 487
ASP A 423
ALA A 424
GLY A 310
GLY A 364
 None
 1.09A 1rjdB-3eh2A:
undetectable		 1rjdB-3eh2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 THR A 487
ASP A 423
ALA A 424
GLY A 310
GLY A 364
 None
 1.08A 1rjdC-3eh2A:
undetectable		 1rjdC-3eh2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 PHE A 439
PHE A 466
ARG A 429
ALA A  70
 None
 1.18A 1rqpC-3eh2A:
2.2		 1rqpC-3eh2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 PHE A 439
PHE A 466
ARG A 429
ALA A  70
 None
 1.13A 1rqpA-3eh2A:
3.2		 1rqpA-3eh2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 CYH A 106
PRO A 107
VAL A  88
TYR A 133
LEU A 137
 None
 1.38A 1z9hA-3eh2A:
undetectable		 1z9hA-3eh2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 CYH A 106
PRO A 107
VAL A  88
TYR A 133
LEU A 137
 None
 1.38A 1z9hB-3eh2A:
1.2		 1z9hB-3eh2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 CYH A 106
PRO A 107
VAL A  88
TYR A 133
LEU A 137
 None
 1.39A 1z9hC-3eh2A:
undetectable		 1z9hC-3eh2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		6 / 12 PHE A 111
PHE A 108
ALA A 103
ALA A 501
PRO A 107
GLY A 155
 None
None
ZN  A 800 ( 4.8A)
None
None
None
 1.32A 2igtA-3eh2A:
undetectable		 2igtA-3eh2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		6 / 12 PHE A 111
PHE A 108
ALA A 103
ALA A 501
PRO A 107
GLY A 155
 None
None
ZN  A 800 ( 4.8A)
None
None
None
 1.35A 2igtB-3eh2A:
undetectable		 2igtB-3eh2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 VAL A 464
PHE A 466
THR A 448
LEU A 480
THR A 430
 None
 1.15A 2jn3A-3eh2A:
undetectable		 2jn3A-3eh2A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 PHE A 439
PHE A 466
ARG A 429
ALA A  70
 None
 1.12A 2v7uA-3eh2A:
undetectable		 2v7uA-3eh2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 273
HIS A 230
ASP A 182
 None
 0.74A 2wa2B-3eh2A:
undetectable		 2wa2B-3eh2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 ARG A 268
GLU A 214
SER A 267
 None
 0.94A 2xkkA-3eh2A:
undetectable
2xkkC-3eh2A:
2.5		 2xkkA-3eh2A:
22.64
2xkkC-3eh2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 6 ILE A 181
THR A 190
PHE A 399
PHE A 408
 None
 1.09A 3elzB-3eh2A:
undetectable		 3elzB-3eh2A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 ILE A  47
ALA A  70
PHE A 466
ALA A 436
 None
 0.89A 3hrdA-3eh2A:
undetectable
3hrdB-3eh2A:
undetectable		 3hrdA-3eh2A:
20.05
3hrdB-3eh2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 SER A 717
ASP A 612
LEU A  78
PRO A  79
 None
 1.19A 3jq7B-3eh2A:
undetectable		 3jq7B-3eh2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 8 SER A 717
ASP A 612
LEU A  78
PRO A  79
 None
 1.07A 3jq7C-3eh2A:
3.5		 3jq7C-3eh2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 LEU A 660
ARG A 605
ASN A 522
 None
 0.66A 3qxvD-3eh2A:
1.3		 3qxvD-3eh2A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 TYR A 396
ASP A 368
ASP A 411
 None
 0.77A 3r24A-3eh2A:
undetectable		 3r24A-3eh2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 THR A  31
ASN A 617
GLU A   7
 None
 0.78A 3v4tA-3eh2A:
undetectable
3v4tC-3eh2A:
1.1		 3v4tA-3eh2A:
20.99
3v4tC-3eh2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 6 ASN A 473
CYH A 504
GLY A 477
ILE A 434
 None
 0.98A 3w9tF-3eh2A:
undetectable		 3w9tF-3eh2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 6 GLY A 299
ARG A 219
ILE A 178
LEU A 229
 None
 1.07A 4acbC-3eh2A:
4.1		 4acbC-3eh2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 LYS A 102
TYR A 104
ARG A 429
 None
 1.35A 4gc9A-3eh2A:
undetectable		 4gc9A-3eh2A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.77A 4k8cA-3eh2A:
3.2		 4k8cA-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.76A 4kahA-3eh2A:
3.4		 4kahA-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.76A 4kahB-3eh2A:
3.0		 4kahB-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.77A 4kanA-3eh2A:
3.1		 4kanA-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.77A 4kanB-3eh2A:
2.8		 4kanB-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.74A 4kbeA-3eh2A:
3.2		 4kbeA-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.75A 4kbeB-3eh2A:
3.4		 4kbeB-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.77A 4lbgA-3eh2A:
3.1		 4lbgA-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		3 / 3 SER A 488
TYR A 486
PRO A 208
 None
 0.76A 4lbgB-3eh2A:
2.8		 4lbgB-3eh2A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 PRO A 622
GLU A   7
GLU A 741
VAL A 579
TYR A 580
 None
 1.42A 4xrgA-3eh2A:
1.3		 4xrgA-3eh2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 4 CYH A  49
LEU A 480
LEU A 502
ALA A 478
 None
 1.06A 5hpuA-3eh2A:
undetectable
5hpuB-3eh2A:
undetectable		 5hpuA-3eh2A:
2.73
5hpuB-3eh2A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 GLY A 221
PHE A 260
VAL A 291
LEU A 312
VAL A 254
 None
 1.22A 5tuiB-3eh2A:
undetectable		 5tuiB-3eh2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		4 / 7 ARG A 435
PHE A 466
LEU A 480
SER A  51
 None
 1.30A 5uxcA-3eh2A:
undetectable		 5uxcA-3eh2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 ILE A 181
LEU A 314
LEU A 275
ALA A 176
GLY A 310
 None
 1.02A 5uxdB-3eh2A:
undetectable		 5uxdB-3eh2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens) 		5 / 12 ALA A 187
GLY A 191
ASP A 182
LEU A 382
LEU A 369
 None
 1.15A 5wwsA-3eh2A:
undetectable		 5wwsA-3eh2A:
21.42