SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 10 SER A 138
VAL A 137
GLY A 136
TYR A 182
GLU A 275
 None
 1.17A 1equA-3eh7A:
undetectable		 1equA-3eh7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 8 PRO A  37
TYR A 141
SER A 142
VAL A 122
 None
 1.20A 1jtvA-3eh7A:
undetectable		 1jtvA-3eh7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 4 LYS A 231
LEU A 228
LEU A 248
SER A 251
 None
 1.42A 1tz8D-3eh7A:
undetectable		 1tz8D-3eh7A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 ASP A 222
GLY A 218
MET A 240
PHE A 270
GLY A 273
 None
 1.09A 2fqyA-3eh7A:
undetectable		 2fqyA-3eh7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 MET A 109
ARG A 343
PRO A 144
VAL A 292
 None
 1.31A 2qd4A-3eh7A:
0.0		 2qd4A-3eh7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 7 GLY A 273
GLY A  65
GLN A 331
PHE A 270
 None
 0.85A 2qwxA-3eh7A:
undetectable
2qwxB-3eh7A:
undetectable		 2qwxA-3eh7A:
21.41
2qwxB-3eh7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 4 SER A 329
GLY A 328
GLY A  65
GLY A  63
 None
 0.72A 3bogB-3eh7A:
undetectable
3bogD-3eh7A:
undetectable		 3bogB-3eh7A:
undetectable
3bogD-3eh7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 7 THR A 391
VAL A 389
ILE A 316
ILE A 369
SER A 367
 None
 1.45A 3deuA-3eh7A:
undetectable		 3deuA-3eh7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 TYR A 182
ALA A  34
GLY A 273
GLU A 275
VAL A 137
 None
 1.14A 3f8wA-3eh7A:
undetectable		 3f8wA-3eh7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 TYR A 182
ALA A  34
GLY A 273
GLU A 275
VAL A 137
 None
 1.12A 3f8wC-3eh7A:
undetectable		 3f8wC-3eh7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 7 VAL A 323
LEU A 318
MET A 355
ILE A 314
 None
 0.93A 3gp0A-3eh7A:
undetectable		 3gp0A-3eh7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 ILE A 357
SER A 324
SER A 329
 None
 0.61A 3iltH-3eh7A:
undetectable		 3iltH-3eh7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 215
ILE A 220
GLY A 200
ALA A 223
LEU A 226
 None
 1.24A 3n8xA-3eh7A:
undetectable		 3n8xA-3eh7A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 393
HIS A 415
ARG A 419
 None
 1.03A 4e7bC-3eh7A:
undetectable		 4e7bC-3eh7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 5 PRO A 263
GLY A 256
ASP A 166
ASP A 286
 None
 1.00A 4n48B-3eh7A:
undetectable		 4n48B-3eh7A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 GLY A  65
GLN A 331
ILE A 217
PHE A 270
 None
 1.02A 4qogA-3eh7A:
undetectable
4qogB-3eh7A:
undetectable		 4qogA-3eh7A:
21.41
4qogB-3eh7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A 422
THR A 391
ILE A 316
ILE A 411
ALA A 407
 None
 1.24A 4rp8C-3eh7A:
undetectable		 4rp8C-3eh7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 5 ILE A  22
VAL A 119
PHE A 135
CYH A  40
 None
 1.22A 4rzvA-3eh7A:
undetectable		 4rzvA-3eh7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 SER A 134
ASP A 243
ASP A 282
 None
 0.61A 4uckA-3eh7A:
undetectable		 4uckA-3eh7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 7 VAL A 370
ILE A 314
ALA A 361
ILE A 327
 None
 0.72A 4uxqA-3eh7A:
undetectable		 4uxqA-3eh7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE
(Porphyromonas
gingivalis) 		4 / 6 ILE A 357
ARG A 368
ILE A 314
GLU A 315
 None
 1.28A 4zzcA-3eh7A:
undetectable
4zzcB-3eh7A:
undetectable		 4zzcA-3eh7A:
21.32
4zzcB-3eh7A:
21.32