SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ehc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 10 VAL A 113
LEU A  71
TYR A   8
TYR A  43
SER A  14
 None
 1.42A 1j78B-3ehcA:
undetectable		 1j78B-3ehcA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 121
ILE A 122
GLN A 125
LEU A  57
PHE A  85
 None
 0.99A 1uduB-3ehcA:
undetectable		 1uduB-3ehcA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 121
ILE A 122
GLN A 125
LEU A  57
PHE A  85
 None
 0.95A 1xozA-3ehcA:
undetectable		 1xozA-3ehcA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 5 ASP A  29
LEU A  23
GLY A  24
ARG A  44
 None
 1.21A 2j2pA-3ehcA:
undetectable
2j2pB-3ehcA:
undetectable		 2j2pA-3ehcA:
22.54
2j2pB-3ehcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 4 ASP A  29
LEU A  23
GLY A  24
ARG A  44
 None
 1.24A 2j2pD-3ehcA:
undetectable
2j2pE-3ehcA:
undetectable		 2j2pD-3ehcA:
22.54
2j2pE-3ehcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 103
LEU A  12
ASN A  16
TYR A  43
 None
 1.12A 2w98A-3ehcA:
undetectable
2w98B-3ehcA:
undetectable		 2w98A-3ehcA:
16.90
2w98B-3ehcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 11 ASN A  16
GLU A  99
LEU A  75
VAL A 101
LEU A  64
 None
 1.31A 3fl9C-3ehcA:
undetectable		 3fl9C-3ehcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 4 GLY A  39
VAL A  31
GLY A  24
THR A  25
 None
 0.92A 3ib2A-3ehcA:
undetectable		 3ib2A-3ehcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		3 / 3 PHE A  59
TYR A  43
TYR A  11
 None
 0.83A 4ffwA-3ehcA:
2.1		 4ffwA-3ehcA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 8 VAL A 113
TYR A 103
LEU A  15
LEU A  47
 None
 0.74A 4jtrA-3ehcA:
undetectable		 4jtrA-3ehcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 12 ARG A  36
ILE A 110
TYR A 103
ARG A  44
LEU A  23
 SO4  A 130 (-3.7A)
None
None
None
None
 1.38A 4kosA-3ehcA:
undetectable		 4kosA-3ehcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 12 ARG A  36
ILE A 110
TYR A 103
ARG A  44
LEU A  23
 SO4  A 130 (-3.7A)
None
None
None
None
 1.33A 4kotA-3ehcA:
undetectable		 4kotA-3ehcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		5 / 11 ARG A  36
ILE A 110
TYR A 103
ARG A  44
LEU A  23
 SO4  A 130 (-3.7A)
None
None
None
None
 1.35A 4koyA-3ehcA:
undetectable		 4koyA-3ehcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ehc SNOAL-LIKE
POLYKETIDE CYCLASE
(Agrobacterium
fabrum) 		4 / 7 ALA A  61
TYR A   8
VAL A 101
GLU A  99
 None
 1.23A 5ecnA-3ehcA:
undetectable		 5ecnA-3ehcA:
13.97