SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ehk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 6 HIS A 170
TRP A 191
PHE A 313
VAL A 314
 None
 1.20A 1ibgH-3ehkA:
undetectable		 1ibgH-3ehkA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 4 ILE A 438
LEU A 439
VAL A 428
ALA A 461
 None
 0.95A 1mz9A-3ehkA:
undetectable		 1mz9A-3ehkA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 5 ILE A 438
LEU A 439
VAL A 428
ALA A 461
 None
 0.97A 1mz9C-3ehkA:
undetectable		 1mz9C-3ehkA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 4 SER A 417
VAL A  48
PHE A 449
VAL A 430
 None
 0.86A 1o86A-3ehkA:
undetectable		 1o86A-3ehkA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3ehk PRUNIN
(Prunus
dulcis) 		5 / 12 ASP A 180
VAL A 182
GLY A  79
ILE A  55
ILE A  72
 None
 0.90A 2r5pA-3ehkA:
undetectable		 2r5pA-3ehkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3ehk PRUNIN
(Prunus
dulcis) 		5 / 12 ASP A 180
VAL A 182
GLY A  79
ILE A  55
ILE A  72
 None
 0.90A 2r5pC-3ehkA:
undetectable		 2r5pC-3ehkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 4 GLU A  29
ARG A 301
ASN A 300
ASP A 299
 None
 1.13A 2zq9A-3ehkA:
undetectable		 2zq9A-3ehkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ehk PRUNIN
(Prunus
dulcis) 		5 / 12 TYR A 402
PHE A 466
GLY A 405
ASN A 404
VAL A 428
 None
 1.19A 2zznA-3ehkA:
undetectable		 2zznA-3ehkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 PHE A 449
TYR A 407
TYR A 468
 None
 1.11A 4ffwA-3ehkA:
undetectable		 4ffwA-3ehkA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3ehk PRUNIN
(Prunus
dulcis) 		5 / 12 GLY A 179
ARG A 367
ILE A  72
ALA A 202
ALA A 183
 None
 1.18A 4kicA-3ehkA:
undetectable		 4kicA-3ehkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 TYR A 223
GLN A  70
TRP A 191
 None
 1.17A 4kn2C-3ehkA:
undetectable		 4kn2C-3ehkA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 6 TYR A 190
GLU A 231
TYR A 223
LEU A  62
 None
 1.24A 4twdD-3ehkA:
undetectable
4twdE-3ehkA:
undetectable		 4twdD-3ehkA:
18.86
4twdE-3ehkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 6 TYR A 190
GLU A 231
TYR A 223
LEU A  62
 None
 1.32A 4twdF-3ehkA:
undetectable
4twdG-3ehkA:
undetectable		 4twdF-3ehkA:
18.86
4twdG-3ehkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.62A 5qgjA-3ehkA:
undetectable		 5qgjA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.61A 5qglA-3ehkA:
undetectable		 5qglA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.66A 5qgmA-3ehkA:
undetectable		 5qgmA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.60A 5qguA-3ehkA:
undetectable		 5qguA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.64A 5qgvA-3ehkA:
undetectable		 5qgvA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.63A 5qgwA-3ehkA:
undetectable		 5qgwA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.64A 5qgxA-3ehkA:
undetectable		 5qgxA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.65A 5qh1A-3ehkA:
undetectable		 5qh1A-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.64A 5qh4A-3ehkA:
undetectable		 5qh4A-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.64A 5qh9A-3ehkA:
undetectable		 5qh9A-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.61A 5qhaA-3ehkA:
undetectable		 5qhaA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.62A 5qhcA-3ehkA:
undetectable		 5qhcA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.61A 5qheA-3ehkA:
undetectable		 5qheA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.64A 5qhfA-3ehkA:
undetectable		 5qhfA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ehk PRUNIN
(Prunus
dulcis) 		3 / 3 VAL A 201
VAL A  75
GLN A 445
 None
 0.67A 5qhgA-3ehkA:
undetectable		 5qhgA-3ehkA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 5 VAL A 271
PRO A 228
GLY A 226
TYR A 223
 None
 1.36A 5x80A-3ehkA:
undetectable
5x80B-3ehkA:
undetectable		 5x80A-3ehkA:
13.45
5x80B-3ehkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3ehk PRUNIN
(Prunus
dulcis) 		4 / 5 LYS A 221
GLN A  70
GLY A  77
ILE A  55
 None
 1.43A 6debB-3ehkA:
undetectable		 6debB-3ehkA:
9.72