SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ehs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A-191
VAL A -90
TRP A  -9
 None
None
MAL  A 126 (-3.7A)
 1.28A 1c4dA-3ehsA:
undetectable
1c4dB-3ehsA:
undetectable		 1c4dA-3ehsA:
3.13
1c4dB-3ehsA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A-189
VAL A   8
LEU A-151
MET A-145
LEU A-198
 None
 1.44A 1nhzA-3ehsA:
undetectable		 1nhzA-3ehsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A-157
LEU A-154
ILE A-188
GLU A-196
LEU A-198
 None
None
None
MAL  A 126 (-3.8A)
None
 1.22A 1wopA-3ehsA:
undetectable		 1wopA-3ehsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A-118
ASP A -53
TYR A-139
ASN A-115
GLY A-121
 None
 1.29A 2dcfA-3ehsA:
undetectable		 2dcfA-3ehsA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A-118
ASP A -53
TYR A-139
ASN A-115
GLY A-121
 None
 1.28A 2zmaA-3ehsA:
undetectable		 2zmaA-3ehsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A-239
GLY A -49
PRO A-120
LYS A -44
 None
 0.66A 3bjwC-3ehsA:
undetectable		 3bjwC-3ehsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A  -6
GLY A-162
ALA A-161
LEU A-157
LEU A-189
 None
 1.05A 3hs6A-3ehsA:
undetectable		 3hs6A-3ehsA:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A-335
LYS A-334
GLU A-305
GLU A-304
ALA A-286
ASP A-284
ARG A-283
GLU A-238
TRP A-119
 MAL  A 126 (-2.9A)
MAL  A 126 (-2.7A)
None
None
MAL  A 126 (-3.1A)
MAL  A 126 (-2.8A)
MAL  A 126 (-4.0A)
MAL  A 126 (-2.6A)
MAL  A 126 ( 4.6A)
 0.67A 3jyrA-3ehsA:
61.2		 3jyrA-3ehsA:
72.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A-335
LYS A-334
GLU A-305
GLU A-304
ALA A-286
ASP A-284
GLU A-238
PRO A-195
TRP A-119
 MAL  A 126 (-2.9A)
MAL  A 126 (-2.7A)
None
None
MAL  A 126 (-3.1A)
MAL  A 126 (-2.8A)
MAL  A 126 (-2.6A)
MAL  A 126 (-3.6A)
MAL  A 126 ( 4.6A)
 0.53A 3jyrA-3ehsA:
61.2		 3jyrA-3ehsA:
72.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A-335
LYS A-334
LYS A-307
GLU A-305
ALA A-286
ASP A-284
ARG A-283
GLU A-238
TRP A-119
 MAL  A 126 (-2.9A)
MAL  A 126 (-2.7A)
None
None
MAL  A 126 (-3.1A)
MAL  A 126 (-2.8A)
MAL  A 126 (-4.0A)
MAL  A 126 (-2.6A)
MAL  A 126 ( 4.6A)
 0.71A 3jyrA-3ehsA:
61.2		 3jyrA-3ehsA:
72.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A-335
LYS A-334
LYS A-307
GLU A-305
ALA A-286
ASP A-284
GLU A-238
PRO A-195
TRP A-119
 MAL  A 126 (-2.9A)
MAL  A 126 (-2.7A)
None
None
MAL  A 126 (-3.1A)
MAL  A 126 (-2.8A)
MAL  A 126 (-2.6A)
MAL  A 126 (-3.6A)
MAL  A 126 ( 4.6A)
 0.52A 3jyrA-3ehsA:
61.2		 3jyrA-3ehsA:
72.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A-337
TRP A-287
GLU A-196
TYR A-194
MET A -19
TRP A  -9
 MAL  A 126 (-4.0A)
MAL  A 126 (-4.4A)
MAL  A 126 (-3.8A)
MAL  A 126 (-4.1A)
MAL  A 126 ( 4.3A)
MAL  A 126 (-3.7A)
 0.22A 3jyrA-3ehsA:
61.2		 3jyrA-3ehsA:
72.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A-153
LEU A-189
GLY A-162
ALA A-161
LEU A  12
 None
 0.99A 3n8yB-3ehsA:
undetectable		 3n8yB-3ehsA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A-193
GLY A -49
LEU A -50
GLU A-238
ALA A-118
 None
None
None
MAL  A 126 (-2.6A)
None
 0.83A 3tbgB-3ehsA:
undetectable		 3tbgB-3ehsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A-193
GLY A -49
LEU A -50
GLU A-238
ALA A-118
 None
None
None
MAL  A 126 (-2.6A)
None
 0.82A 3tbgD-3ehsA:
undetectable		 3tbgD-3ehsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		3 / 3 SER A  40
GLY A  41
GLN A  43
 None
 0.63A 3v4tH-3ehsA:
1.3		 3v4tH-3ehsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A-118
ASP A -53
TYR A-139
ASN A-115
GLY A-121
 None
 1.29A 3vwpA-3ehsA:
0.0		 3vwpA-3ehsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A-118
ASP A -53
TYR A-139
ASN A-115
GLY A-121
 None
 1.29A 3vwrA-3ehsA:
undetectable		 3vwrA-3ehsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A -41
ASP A -35
ASP A -62
ASN A -55
 None
 1.38A 3vywD-3ehsA:
undetectable		 3vywD-3ehsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A -85
ALA A-244
LEU A-246
LEU A -87
VAL A -88
 None
 1.17A 4or0B-3ehsA:
undetectable		 4or0B-3ehsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A  55
ARG A  66
LEU A  63
 None
 0.91A 5dbyA-3ehsA:
undetectable		 5dbyA-3ehsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		4 / 8 GLY A-183
LYS A-160
ALA A-159
ASP A-165
 None
 0.85A 5mvsB-3ehsA:
undetectable		 5mvsB-3ehsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A  -7
ALA A -11
GLY A-183
ALA A-161
PHE A-180
VAL A-168
 None
 1.47A 5w4zA-3ehsA:
undetectable		 5w4zA-3ehsA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A-194
ASN A-122
LEU A-236
 MAL  A 126 (-4.1A)
None
None
 0.83A 6b58A-3ehsA:
undetectable		 6b58A-3ehsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A-216
GLU A-219
PRO A -95
ALA A-186
PRO A-190
 None
 1.37A 6bm5A-3ehsA:
undetectable		 6bm5A-3ehsA:
23.49