SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ejb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 11 LEU B 251
ALA B 139
ALA B 135
VAL B 391
LEU B 361
 None
 0.99A 1hbpA-3ejbB:
undetectable		 1hbpA-3ejbB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 9 LEU B  62
GLY B 180
VAL B  75
ILE B 229
ILE B 165
 None
 1.02A 1hpvA-3ejbB:
undetectable		 1hpvA-3ejbB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 8 LEU B 362
ALA B 270
ILE B 267
CYH B 249
PHE B 325
 None
 1.38A 1sv9A-3ejbB:
undetectable		 1sv9A-3ejbB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 ILE B 358
ALA B 270
ASN B 245
LEU B 260
LEU B 242
 None
None
None
None
HEM  B 405 ( 4.5A)
 1.13A 1xdkA-3ejbB:
undetectable		 1xdkA-3ejbB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 ALA B 135
ILE B 131
ILE B 243
VAL B 247
LEU B 370
 None
 1.00A 1xozA-3ejbB:
undetectable		 1xozA-3ejbB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 6 THR B 227
GLU B 223
MET B 188
ILE B 195
 None
 1.33A 2w98B-3ejbB:
undetectable		 2w98B-3ejbB:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		6 / 12 MET B  79
ASN B 181
LEU B 230
ILE B 233
ALA B 234
THR B 238
 None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
 0.76A 3a50A-3ejbB:
47.2		 3a50A-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		6 / 11 MET B  79
LEU B 164
ASN B 181
LEU B 230
ILE B 233
THR B 238
 None
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
 0.85A 3a50B-3ejbB:
47.5		 3a50B-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 11 MET B  79
LEU B 164
LEU B 230
ILE B 233
PRO B  61
 None
None
HEM  B 405 ( 4.6A)
None
None
 1.34A 3a50B-3ejbB:
47.5		 3a50B-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		6 / 11 MET B  79
LEU B 164
ASN B 181
LEU B 230
ILE B 233
THR B 238
 None
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
 0.82A 3a50C-3ejbB:
47.5		 3a50C-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		6 / 12 MET B  79
LEU B 164
ASN B 181
ILE B 233
ALA B 234
THR B 238
 None
None
None
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
 0.81A 3a50D-3ejbB:
47.5		 3a50D-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		6 / 12 MET B  79
LEU B 164
ASN B 181
LEU B 230
ILE B 233
THR B 238
 None
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
 0.72A 3a50E-3ejbB:
47.3		 3a50E-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 MET B  79
ASN B 181
LEU B 230
ILE B 233
THR B 238
 None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
 0.85A 3a51D-3ejbB:
47.6		 3a51D-3ejbB:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 MET B  79
ASN B 181
ILE B 233
ALA B 234
THR B 238
 None
None
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
 0.67A 3a51E-3ejbB:
47.4		 3a51E-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		3 / 3 ALA B 234
THR B 238
CYH B 344
 HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
HEM  B 405 (-2.3A)
 0.52A 3e4eA-3ejbB:
33.2		 3e4eA-3ejbB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		3 / 3 ALA B 234
THR B 238
CYH B 344
 HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
HEM  B 405 (-2.3A)
 0.40A 3e4eB-3ejbB:
33.2		 3e4eB-3ejbB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 6 LEU B  81
ILE B 233
ALA B 234
THR B 238
 HEM  B 405 (-4.3A)
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
 0.74A 3mdrA-3ejbB:
35.7		 3mdrA-3ejbB:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 10 LEU B 164
LEU B 230
ILE B 233
ALA B 234
THR B 238
 None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
 0.53A 3r9cA-3ejbB:
46.6		 3r9cA-3ejbB:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 8 GLN B 123
HIS B 116
LEU B 361
THR B 360
 None
 0.91A 3w6hA-3ejbB:
undetectable		 3w6hA-3ejbB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 LEU B 352
ALA B 270
LEU B 118
PHE B 134
THR B 360
 None
 1.47A 4iarA-3ejbB:
undetectable		 4iarA-3ejbB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		3 / 3 ARG B 378
GLU B 237
ASN B 241
 None
 0.83A 4imaD-3ejbB:
undetectable		 4imaD-3ejbB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		3 / 3 ARG B 378
GLU B 237
ASN B 241
 None
 0.88A 4ip7D-3ejbB:
undetectable		 4ip7D-3ejbB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 11 VAL B 240
ILE B 243
ILE B 111
ILE B 356
PHE B 134
 None
 1.21A 5hw8D-3ejbB:
undetectable		 5hw8D-3ejbB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 5 TYR B  19
ASP B 315
PRO B 316
ALA B 312
 None
 1.03A 5otrA-3ejbB:
undetectable		 5otrA-3ejbB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 7 HIS B  26
PRO B  27
ILE B  28
SER B 317
 None
 0.54A 5vkqA-3ejbB:
undetectable
5vkqD-3ejbB:
undetectable		 5vkqA-3ejbB:
13.92
5vkqD-3ejbB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 7 SER B 317
HIS B  26
PRO B  27
ILE B  28
 None
 0.61A 5vkqA-3ejbB:
undetectable
5vkqB-3ejbB:
undetectable		 5vkqA-3ejbB:
13.92
5vkqB-3ejbB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 8 SER B 317
HIS B  26
PRO B  27
ILE B  28
 None
 0.59A 5vkqB-3ejbB:
undetectable
5vkqC-3ejbB:
undetectable		 5vkqB-3ejbB:
13.92
5vkqC-3ejbB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 7 SER B 317
HIS B  26
PRO B  27
ILE B  28
 None
 0.57A 5vkqC-3ejbB:
undetectable
5vkqD-3ejbB:
undetectable		 5vkqC-3ejbB:
13.92
5vkqD-3ejbB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 7 LEU B 230
ALA B 234
THR B 238
THR B 281
 HEM  B 405 ( 4.6A)
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
HEM  B 405 (-4.1A)
 0.64A 6a7jA-3ejbB:
44.0		 6a7jA-3ejbB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 6 VAL B 247
LEU B 260
LEU B 257
HIS B 253
 None
None
None
CL  B 406 (-4.7A)
 0.92A 6e43B-3ejbB:
undetectable		 6e43B-3ejbB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		4 / 6 VAL B 247
LEU B 260
LEU B 257
HIS B 253
 None
None
None
CL  B 406 (-4.7A)
 0.90A 6e43C-3ejbB:
undetectable		 6e43C-3ejbB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 12 LEU B 352
ILE B 143
ILE B 356
VAL B 115
ILE B 111
 None
 1.01A 6emuA-3ejbB:
undetectable		 6emuA-3ejbB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME
(Bacillus
subtilis) 		5 / 10 VAL B 391
LEU B 368
LEU B 361
LEU B 250
LEU B 251
 None
 1.02A 6f6nA-3ejbB:
undetectable
6f6nB-3ejbB:
undetectable		 6f6nA-3ejbB:
12.15
6f6nB-3ejbB:
13.27