SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ejg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		5 / 9 LEU A  45
VAL A  22
VAL A 150
GLY A  17
LEU A  49
 None
 1.48A 1lwfA-3ejgA:
1.7		 1lwfA-3ejgA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		3 / 3 ALA A  34
GLY A 124
SER A 133
 None
 0.57A 2ivuA-3ejgA:
undetectable		 2ivuA-3ejgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		3 / 3 THR A 152
ASP A 161
SER A 164
 None
 0.78A 2nxeA-3ejgA:
undetectable		 2nxeA-3ejgA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		3 / 3 THR A 152
ASP A 161
SER A 164
 None
 0.73A 2nxeB-3ejgA:
2.0		 2nxeB-3ejgA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		5 / 12 GLY A  42
ALA A  40
ASN A  36
SER A 122
GLY A  91
 None
 1.19A 2vmyB-3ejgA:
undetectable		 2vmyB-3ejgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		5 / 12 GLY A  43
GLY A  42
ASP A  18
ASP A  50
LEU A  84
 None
 0.97A 3m6vA-3ejgA:
undetectable		 3m6vA-3ejgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		5 / 12 GLY A  43
GLY A  42
ASP A  18
ASP A  50
LEU A  84
 None
 0.99A 3m6vB-3ejgA:
undetectable		 3m6vB-3ejgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 7 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.98A 4a97E-3ejgA:
undetectable		 4a97E-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 8 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.99A 4a97C-3ejgA:
undetectable		 4a97C-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 8 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.96A 4a97D-3ejgA:
undetectable		 4a97D-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 8 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.94A 4a97G-3ejgA:
undetectable		 4a97G-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 7 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.96A 4a97H-3ejgA:
undetectable		 4a97H-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 8 PHE A   6
TYR A  15
VAL A 150
ILE A 120
 None
 0.99A 4a97I-3ejgA:
undetectable		 4a97I-3ejgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 6 PHE A 126
LEU A  45
PRO A 119
ARG A  93
 None
 1.36A 4yv5B-3ejgA:
undetectable		 4yv5B-3ejgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 6 PHE A 126
LEU A  45
PRO A 119
ARG A  93
 None
 1.39A 4yv5A-3ejgA:
undetectable		 4yv5A-3ejgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3ejg NON-STRUCTURAL
PROTEIN 3
(Human
coronavirus
229E) 		4 / 4 HIS A  41
VAL A  71
LEU A  39
ALA A  35
 None
 1.44A 6d8pB-3ejgA:
3.6		 6d8pB-3ejgA:
14.17