SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ejw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 12 LEU A 110
PHE A 305
PHE A 315
LEU A 298
PHE A 220
 None
 1.38A 1brpA-3ejwA:
undetectable		 1brpA-3ejwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		3 / 3 ALA A   5
VAL A  64
TRP A  89
 None
 0.96A 1c4dA-3ejwA:
undetectable
1c4dB-3ejwA:
undetectable		 1c4dA-3ejwA:
5.17
1c4dB-3ejwA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		3 / 3 TRP A  89
ALA A   5
VAL A  64
 None
 0.87A 1c4dA-3ejwA:
undetectable
1c4dB-3ejwA:
undetectable		 1c4dA-3ejwA:
5.17
1c4dB-3ejwA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 9 TYR A  36
VAL A  13
GLY A  14
THR A 222
VAL A 243
 None
 1.46A 1dz8A-3ejwA:
undetectable		 1dz8A-3ejwA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		3 / 3 ILE A 310
ASP A 314
PHE A 315
 None
 0.65A 1uwjB-3ejwA:
undetectable		 1uwjB-3ejwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		4 / 7 GLY A 311
PHE A 313
PRO A 223
THR A 303
 None
 1.09A 2aouB-3ejwA:
3.0		 2aouB-3ejwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 10 PHE A  15
ASP A 140
ILE A 297
PHE A   6
ILE A 271
 PAV  A 400 (-3.7A)
PAV  A 400 (-3.1A)
None
None
None
 1.28A 2v0mA-3ejwA:
undetectable		 2v0mA-3ejwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 10 PHE A  15
ILE A 297
PHE A   6
ILE A 271
GLY A  19
 PAV  A 400 (-3.7A)
None
None
None
None
 1.38A 2v0mA-3ejwA:
undetectable		 2v0mA-3ejwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		4 / 7 ILE A 181
ALA A 130
VAL A 129
ALA A 202
 None
 0.71A 4g77A-3ejwA:
2.3		 4g77A-3ejwA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		4 / 4 ALA A 198
ALA A 201
ALA A 202
ALA A 205
 None
 0.10A 4oadA-3ejwA:
undetectable		 4oadA-3ejwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		4 / 4 ALA A 198
ALA A 201
ALA A 202
ALA A 205
 None
 0.09A 4oaeA-3ejwA:
undetectable		 4oaeA-3ejwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 9 SER A 250
ILE A  63
GLY A  19
ALA A  21
VAL A  34
 None
 1.23A 4r1zA-3ejwA:
undetectable		 4r1zA-3ejwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 12 ASP A  90
GLU A 301
GLY A 247
ALA A  23
PHE A 315
 PAV  A 400 (-2.8A)
None
None
None
None
 1.21A 4xe5A-3ejwA:
3.2		 4xe5A-3ejwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 12 PRO A  42
ILE A   7
LEU A  10
VAL A  67
LEU A  62
 None
 1.12A 5bykA-3ejwA:
undetectable		 5bykA-3ejwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3ejw SMLSRB
(Sinorhizobium
meliloti) 		5 / 12 PRO A  42
ILE A   7
LEU A  10
VAL A  67
LEU A  62
 None
 1.02A 6b52A-3ejwA:
1.6		 6b52A-3ejwA:
19.57