SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ek2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 8 ALA A 149
LEU A 166
ALA A 186
THR A 143
 None
 0.94A 1ie4B-3ek2A:
undetectable
1ie4D-3ek2A:
undetectable		 1ie4B-3ek2A:
19.71
1ie4D-3ek2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 8 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.69A 2bfpA-3ek2A:
25.7		 2bfpA-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 8 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.71A 2bfpB-3ek2A:
25.6		 2bfpB-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 8 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.74A 2bfpC-3ek2A:
25.5		 2bfpC-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 8 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.78A 2bfpD-3ek2A:
25.5		 2bfpD-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 6 GLY A 229
LEU A 142
ASN A 185
GLU A 243
 None
 0.86A 3zqtA-3ek2A:
undetectable		 3zqtA-3ek2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		3 / 3 TYR A 122
ASP A  68
ASP A  64
 None
 0.86A 4a6eA-3ek2A:
5.1		 4a6eA-3ek2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		5 / 12 ALA A  27
ARG A  30
ALA A 228
LEU A 144
ILE A 187
 None
 1.15A 4lnwA-3ek2A:
undetectable		 4lnwA-3ek2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		5 / 12 ALA A  27
ARG A  30
ALA A 228
LEU A 144
ILE A 187
 None
 1.15A 4lnxA-3ek2A:
undetectable		 4lnxA-3ek2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 6 ASP A 138
ASP A  86
ALA A  33
ASP A 235
 None
 1.15A 4mdaA-3ek2A:
undetectable		 4mdaA-3ek2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 6 ASP A 138
ASP A  86
ALA A  33
ASP A 235
 None
 1.20A 4mdbA-3ek2A:
undetectable		 4mdbA-3ek2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		5 / 12 LEU A  78
LEU A 135
ALA A 131
THR A 143
ALA A 139
 None
 1.20A 4x1kA-3ek2A:
5.5
4x1kB-3ek2A:
5.3		 4x1kA-3ek2A:
20.97
4x1kB-3ek2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		6 / 12 LEU A 141
ALA A 131
LEU A  78
LEU A 135
GLY A  87
LEU A  10
 None
 1.46A 5h2uA-3ek2A:
undetectable		 5h2uA-3ek2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		3 / 3 ARG A  30
PHE A  51
LEU A  35
 None
 0.76A 5veuA-3ek2A:
undetectable		 5veuA-3ek2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 7 SER A 188
VAL A 220
PRO A 191
ILE A 206
 None
 1.21A 5vkqA-3ek2A:
undetectable
5vkqB-3ek2A:
undetectable		 5vkqA-3ek2A:
10.28
5vkqB-3ek2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		4 / 7 SER A 188
VAL A 220
PRO A 191
ILE A 206
 None
 1.20A 5vkqC-3ek2A:
undetectable
5vkqD-3ek2A:
undetectable		 5vkqC-3ek2A:
10.28
5vkqD-3ek2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)
(Burkholderia
pseudomallei) 		5 / 12 ALA A 230
GLY A 226
GLY A  23
LEU A 236
PHE A   3
 None
 1.14A 5ybbA-3ek2A:
4.4		 5ybbA-3ek2A:
21.50