SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ekm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASP A  38
PHE A 305
VAL A  67
 None
 0.55A 1kijB-3ekmA:
undetectable		 1kijB-3ekmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 192
LEU A 239
ALA A 265
GLU A 268
 None
 0.95A 1xvaA-3ekmA:
undetectable
1xvaB-3ekmA:
undetectable		 1xvaA-3ekmA:
20.88
1xvaB-3ekmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 LEU A 284
GLY A 146
ALA A 258
ILE A 286
 None
 0.79A 2aohB-3ekmA:
undetectable		 2aohB-3ekmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A  94
GLU A 245
ASP A  38
 None
ZDR  A 500 (-3.0A)
None
 0.91A 2avdB-3ekmA:
undetectable		 2avdB-3ekmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 LEU A 284
GLY A 146
ILE A 131
ALA A 258
ILE A 286
 None
 1.05A 3el0B-3ekmA:
undetectable		 3el0B-3ekmA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 249
GLY A  71
GLY A 247
LEU A  60
ASP A  70
 None
 0.95A 3embA-3ekmA:
undetectable		 3embA-3ekmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 HIS A 190
ASN A 227
ARG A 246
GLU A  97
 None
ZDR  A 500 (-3.0A)
ZDR  A 500 (-3.7A)
None
 1.40A 3galA-3ekmA:
undetectable		 3galA-3ekmA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 249
GLY A  71
GLY A 247
LEU A  60
ASP A  70
 None
 0.99A 3gczA-3ekmA:
undetectable		 3gczA-3ekmA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
GLY A 198
VAL A 231
ARG A 270
VAL A 184
 None
 0.94A 3m6wA-3ekmA:
undetectable		 3m6wA-3ekmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A  74
ILE A  52
ALA A  57
ALA A  69
 None
 1.01A 3mdrB-3ekmA:
undetectable		 3mdrB-3ekmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A  68
SER A  91
ASP A  70
ASP A  92
ASN A  64
 None
 1.18A 3v8vB-3ekmA:
undetectable		 3v8vB-3ekmA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASN A  37
LEU A 261
MET A 297
CYH A  99
PHE A  39
 ZDR  A 500 (-3.4A)
None
None
ZDR  A 500 (-3.0A)
None
 1.46A 3vhuA-3ekmA:
undetectable		 3vhuA-3ekmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 131
ILE A 286
VAL A 277
ASN A 101
ASN A  37
 None
None
None
ZDR  A 500 (-3.7A)
ZDR  A 500 (-3.4A)
 1.09A 4a81A-3ekmA:
undetectable		 4a81A-3ekmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 THR A 126
ILE A 131
VAL A 143
GLY A 102
 None
 0.83A 4eq4B-3ekmA:
undetectable		 4eq4B-3ekmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ARG A 246
GLY A 247
ASN A  37
GLU A 245
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.4A)
ZDR  A 500 (-3.0A)
 0.82A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ARG A 246
GLY A 247
GLU A 245
GLN A  54
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.0A)
None
 1.21A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 269
ALA A 265
LEU A 150
THR A 182
ILE A 192
 None
 1.22A 4hytA-3ekmA:
undetectable		 4hytA-3ekmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 269
ALA A 265
LEU A 150
THR A 182
ILE A 192
 None
 1.21A 4hytC-3ekmA:
undetectable		 4hytC-3ekmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 257
GLY A 255
GLY A 100
GLU A 245
HIS A 190
 None
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.0A)
None
 1.15A 4l8fB-3ekmA:
undetectable		 4l8fB-3ekmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 257
GLY A 255
GLY A 100
GLU A 245
HIS A 190
 None
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.0A)
None
 1.14A 4l8fD-3ekmA:
undetectable		 4l8fD-3ekmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 255
ALA A 258
GLY A 257
THR A 193
LEU A 261
 ZDR  A 500 (-3.6A)
None
None
None
None
 0.93A 4o33A-3ekmA:
undetectable		 4o33A-3ekmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 255
ALA A 258
GLY A 257
THR A 193
LEU A 261
 ZDR  A 500 (-3.6A)
None
None
None
None
 0.82A 4o3fA-3ekmA:
undetectable		 4o3fA-3ekmA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 209
ASN A 208
PRO A 210
ARG A  63
 None
 1.37A 4yv5B-3ekmA:
undetectable		 4yv5B-3ekmA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 12 LEU A 130
GLY A 127
ALA A 128
PRO A 133
VAL A 132
ILE A 131
 None
 1.43A 6dilB-3ekmA:
undetectable		 6dilB-3ekmA:
14.63