SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3el6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		4 / 7 GLY A 137
ASP A 260
HIS A 264
ALA A 262
 None
 0.94A 1gxsA-3el6A:
undetectable
1gxsB-3el6A:
undetectable		 1gxsA-3el6A:
20.36
1gxsB-3el6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 10 LEU A  15
ALA A  64
VAL A 108
ALA A 126
LEU A  82
 None
 1.10A 1xp0A-3el6A:
undetectable		 1xp0A-3el6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A  86
LEU A  82
VAL A  56
ALA A  87
GLY A  31
 None
 1.38A 2vmyB-3el6A:
undetectable		 2vmyB-3el6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		4 / 8 LEU A  60
ALA A  89
LEU A  33
ILE A 106
 None
 0.93A 3cldB-3el6A:
undetectable		 3cldB-3el6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A  54
VAL A  58
GLY A 128
THR A 129
 None
 0.91A 3ib2A-3el6A:
undetectable		 3ib2A-3el6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.34A 4eilA-3el6A:
undetectable		 4eilA-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 10 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.34A 4eilB-3el6A:
undetectable		 4eilB-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.31A 4eilC-3el6A:
undetectable		 4eilC-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.31A 4eilE-3el6A:
undetectable		 4eilE-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.33A 4kyaA-3el6A:
undetectable		 4kyaA-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.31A 4kyaE-3el6A:
undetectable		 4kyaE-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 11 VAL A  52
SER A  34
LEU A  14
VAL A  56
THR A  50
 None
 1.32A 4kyaG-3el6A:
undetectable		 4kyaG-3el6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 9 TYR A 158
TYR A 168
VAL A 203
HIS A 157
LEU A 214
 None
 1.46A 4l1xB-3el6A:
undetectable		 4l1xB-3el6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		4 / 8 PRO A  53
SER A  55
VAL A  56
VAL A  45
 None
 0.75A 4mk4A-3el6A:
undetectable		 4mk4A-3el6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		3 / 3 ALA A 178
GLN A 173
GLY A 169
 None
 0.62A 4odoC-3el6A:
undetectable		 4odoC-3el6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 9 LEU A 204
SER A  55
VAL A 269
VAL A 258
LEU A 272
 None
 1.43A 4wnvA-3el6A:
undetectable		 4wnvA-3el6A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 175
LEU A 212
ALA A 246
VAL A 244
ALA A 187
 None
 1.08A 4x1iB-3el6A:
undetectable		 4x1iB-3el6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		4 / 7 TYR A 198
VAL A 203
HIS A  12
LEU A  60
 None
 1.09A 4xo7B-3el6A:
undetectable		 4xo7B-3el6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3el6 ERYTHROMYCIN
DEHYDRATASE
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A  21
ASP A  20
ALA A  97
GLY A  69
LEU A  70
 None
CL  A 290 (-4.1A)
None
None
None
 1.05A 5m54E-3el6A:
undetectable		 5m54E-3el6A:
20.05