SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ele'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		6 / 12 ILE A 176
LEU A 200
THR A 239
PRO A 210
LEU A 118
ILE A 214
 None
 1.43A 1cd2A-3eleA:
undetectable		 1cd2A-3eleA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.02A 1cqeA-3eleA:
undetectable		 1cqeA-3eleA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.04A 1cqeB-3eleA:
undetectable		 1cqeB-3eleA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 ALA A 339
ILE A 391
TYR A 324
ILE A 358
 None
 0.95A 1oniD-3eleA:
undetectable
1oniF-3eleA:
undetectable		 1oniD-3eleA:
16.03
1oniF-3eleA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 PHE A 333
SER A 373
ILE A 372
ILE A  17
TYR A 334
 None
 1.40A 1ot7A-3eleA:
0.0		 1ot7A-3eleA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 5 ASP A 330
PRO A 230
VAL A 229
ILE A 227
 None
 0.89A 2aoiA-3eleA:
undetectable		 2aoiA-3eleA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 PHE A 133
ILE A 214
ILE A 177
THR A 128
LEU A 147
 PLP  A 500 (-4.0A)
None
None
None
None
 1.19A 2bjfA-3eleA:
undetectable		 2bjfA-3eleA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 GLU A 155
CYH A 366
ASP A 153
ALA A 152
ALA A 130
 None
 1.17A 2br4B-3eleA:
2.7		 2br4B-3eleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 CYH A 326
PHE A  39
PHE A 388
TYR A 374
 None
 1.47A 3hggA-3eleA:
undetectable		 3hggA-3eleA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 VAL A 275
ALA A 278
GLY A 279
ALA A 142
LEU A 240
 None
 1.17A 3qxyA-3eleA:
undetectable		 3qxyA-3eleA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 11 VAL A 275
ALA A 278
GLY A 279
ALA A 142
LEU A 240
 None
 1.15A 3rc0A-3eleA:
undetectable		 3rc0A-3eleA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 VAL A 275
ALA A 278
GLY A 279
ALA A 142
LEU A 240
 None
 1.14A 3rc0B-3eleA:
undetectable		 3rc0B-3eleA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.06A 3rr3A-3eleA:
undetectable		 3rr3A-3eleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.05A 3rr3B-3eleA:
undetectable		 3rr3B-3eleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 ALA A 130
PRO A 131
ARG A 371
ALA A 361
 None
 0.79A 3twpA-3eleA:
2.0		 3twpA-3eleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 ALA A 130
PRO A 131
ARG A 371
ALA A 361
 None
 0.98A 3twpB-3eleA:
undetectable		 3twpB-3eleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 8 TYR A 219
ILE A 177
ASN A 178
GLU A 221
 PLP  A 500 (-4.4A)
None
PLP  A 500 (-3.0A)
EDO  A 501 ( 3.8A)
 0.94A 4a97C-3eleA:
undetectable		 4a97C-3eleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.08A 4coxA-3eleA:
undetectable		 4coxA-3eleA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.09A 4coxB-3eleA:
undetectable		 4coxB-3eleA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.09A 4coxC-3eleA:
undetectable		 4coxC-3eleA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 1.09A 4coxD-3eleA:
undetectable		 4coxD-3eleA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 8 ASN A 345
ALA A 346
LYS A 350
GLU A 353
 None
 0.88A 4zbqA-3eleA:
undetectable		 4zbqA-3eleA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 9 VAL A 337
PHE A 347
ILE A 391
PHE A 388
LEU A 319
 None
 1.38A 5e4dA-3eleA:
1.4		 5e4dA-3eleA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 VAL A 241
THR A 239
ARG A 220
THR A  94
 None
 1.03A 5e4dA-3eleA:
1.4
5e4dB-3eleA:
1.4		 5e4dA-3eleA:
18.97
5e4dB-3eleA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		3 / 3 PRO A  44
ILE A 358
SER A 246
 None
None
PLP  A 500 (-2.7A)
 0.74A 5fsaA-3eleA:
undetectable		 5fsaA-3eleA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 4 CYH A 114
PHE A 115
ILE A 177
GLY A 174
 None
 1.47A 5hesB-3eleA:
0.5		 5hesB-3eleA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 8 ILE A 391
LEU A 315
ILE A 381
LEU A 340
 None
 0.90A 5ieoA-3eleA:
undetectable		 5ieoA-3eleA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 0.96A 5jvzA-3eleA:
undetectable		 5jvzA-3eleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 12 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 0.96A 5jvzB-3eleA:
undetectable		 5jvzB-3eleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		5 / 9 ALA A 215
ASP A 216
GLY A 174
ILE A 211
ILE A 177
 None
PLP  A 500 (-2.8A)
None
None
None
 1.11A 5kr0A-3eleA:
undetectable		 5kr0A-3eleA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 8 THR A 320
LEU A 319
TYR A 324
VAL A 370
 None
 1.25A 5ov9B-3eleA:
undetectable		 5ov9B-3eleA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		3 / 3 MET A 103
GLU A  79
ARG A  81
 None
 0.85A 5tjzA-3eleA:
4.4		 5tjzA-3eleA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3ele AMINO TRANSFERASE
([Eubacterium]
rectale) 		4 / 7 ASN A 345
ALA A 346
LYS A 350
GLU A 353
 None
 0.91A 6ci6A-3eleA:
undetectable		 6ci6A-3eleA:
11.90