SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3els'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 198
THR A 165
LEU A 188
LEU A 186
 None
 1.01A 1u18B-3elsA:
undetectable		 1u18B-3elsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  80
TYR A  96
ILE A  82
GLY A 107
 None
 0.90A 2du8A-3elsA:
undetectable		 2du8A-3elsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 141
VAL A 106
GLY A 107
ILE A  82
ILE A 200
 None
 1.04A 3ijdB-3elsA:
undetectable		 3ijdB-3elsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 201
LEU A 180
ILE A 172
PRO A 173
LEU A 186
 None
None
None
CL  A 205 ( 4.8A)
None
 1.19A 3nrrA-3elsA:
undetectable		 3nrrA-3elsA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.02A 3qx3A-3elsA:
undetectable		 3qx3A-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.05A 3qx3B-3elsA:
undetectable		 3qx3B-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 192
SER A 189
GLY A 164
THR A 165
SER A 136
 None
 1.46A 3r75A-3elsA:
undetectable		 3r75A-3elsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 192
SER A 189
GLY A 164
THR A 165
SER A 136
 None
 1.45A 3r75B-3elsA:
undetectable		 3r75B-3elsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 186
LEU A 167
PRO A 173
ILE A 172
 None
None
CL  A 205 ( 4.8A)
None
 0.74A 3s56B-3elsA:
undetectable		 3s56B-3elsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 162
SER A 161
SER A 137
SER A 189
 None
 1.37A 5hswA-3elsA:
undetectable		 5hswA-3elsA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 180
ILE A 172
ILE A 200
GLU A  79
PHE A 201
 None
None
None
GOL  A 206 (-3.6A)
None
 1.43A 5igzA-3elsA:
undetectable		 5igzA-3elsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.11A 5zrfB-3elsA:
undetectable		 5zrfB-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.08A 5zrfA-3elsA:
0.0		 5zrfA-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 181
LYS A 153
TYR A 155
 None
 1.28A 6gnaA-3elsA:
undetectable		 6gnaA-3elsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3els PRE-MRNA LEAKAGE
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 181
LYS A 153
TYR A 155
 None
 1.28A 6gnbA-3elsA:
undetectable		 6gnbA-3elsA:
18.84