SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3emj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.05A 1qzfA-3emjA:
undetectable		 1qzfA-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.06A 1qzfB-3emjA:
undetectable		 1qzfB-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.05A 1qzfC-3emjA:
undetectable		 1qzfC-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.05A 1qzfD-3emjA:
undetectable		 1qzfD-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.06A 1qzfE-3emjA:
undetectable		 1qzfE-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		3 / 3 ASP A  65
GLU A  20
ARG A  43
 None
 0.84A 1wopA-3emjA:
undetectable		 1wopA-3emjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		3 / 3 ASP A  65
GLU A  20
TYR A 141
 None
 0.81A 1wsvA-3emjA:
undetectable		 1wsvA-3emjA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.07A 2oipA-3emjA:
undetectable		 2oipA-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 GLY A  56
ASP A  42
TYR A  55
ARG A  43
 None
 1.10A 3arrA-3emjA:
undetectable		 3arrA-3emjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 LEU A 123
ILE A 134
ARG A 133
GLY A 156
ALA A 161
 None
 1.05A 3lbdA-3emjA:
undetectable		 3lbdA-3emjA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 10 ALA A  75
ASP A 114
ILE A 106
VAL A  17
ILE A  85
 None
 1.03A 4dqcA-3emjA:
undetectable		 4dqcA-3emjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.19A 4feuB-3emjA:
undetectable		 4feuB-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.13A 4feuF-3emjA:
undetectable		 4feuF-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.17A 4fevD-3emjA:
undetectable		 4fevD-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.14A 4fevF-3emjA:
undetectable		 4fevF-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.16A 4fewD-3emjA:
undetectable		 4fewD-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.16A 4fewF-3emjA:
undetectable		 4fewF-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.14A 4fexB-3emjA:
undetectable		 4fexB-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.12A 4gkhB-3emjA:
undetectable		 4gkhB-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.17A 4gkhF-3emjA:
undetectable		 4gkhF-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 7 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.16A 4gkhG-3emjA:
undetectable		 4gkhG-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.15A 4gkhC-3emjA:
undetectable
4gkhK-3emjA:
undetectable		 4gkhC-3emjA:
23.75
4gkhK-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.17A 4gkiA-3emjA:
undetectable		 4gkiA-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 ASP A  42
ASP A 102
GLU A 145
GLU A  31
 None
 1.15A 4gkiC-3emjA:
undetectable		 4gkiC-3emjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.11A 4ky8A-3emjA:
undetectable		 4ky8A-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.12A 4ky8B-3emjA:
undetectable		 4ky8B-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.12A 4ky8D-3emjA:
undetectable		 4ky8D-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.12A 4ky8E-3emjA:
undetectable		 4ky8E-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.10A 4q0dA-3emjA:
undetectable		 4q0dA-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.10A 4q0dB-3emjA:
undetectable		 4q0dB-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 108
ALA A  89
LEU A 123
ILE A 134
LEU A 130
 None
 1.10A 4q0dE-3emjA:
undetectable		 4q0dE-3emjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3emj INORGANIC
PYROPHOSPHATASE
(Rickettsia
prowazekii) 		4 / 8 PRO A  59
ILE A  15
THR A  61
ILE A 169
 None
 0.95A 5mzrE-3emjA:
undetectable		 5mzrE-3emjA:
17.92