SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3emk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.04A 1eqhA-3emkA:
undetectable		 1eqhA-3emkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.00A 1eqhB-3emkA:
undetectable		 1eqhB-3emkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 8 ALA A  74
GLU A  75
LEU A 122
ARG A 129
 None
 0.86A 1ereE-3emkA:
undetectable		 1ereE-3emkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 8 ALA A  74
GLU A  75
LEU A 122
ARG A 129
 None
 0.86A 1ereF-3emkA:
undetectable		 1ereF-3emkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.17A 1mj2A-3emkA:
undetectable		 1mj2A-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.19A 1mjoA-3emkA:
undetectable		 1mjoA-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.20A 1mjoB-3emkA:
undetectable		 1mjoB-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.21A 1mjoC-3emkA:
undetectable		 1mjoC-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.16A 1mjqI-3emkA:
undetectable
1mjqJ-3emkA:
undetectable		 1mjqI-3emkA:
14.23
1mjqJ-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 6 ASN A 178
LEU A 159
LEU A 166
ILE A 160
 None
 0.98A 1z95A-3emkA:
undetectable		 1z95A-3emkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		6 / 12 LEU A 118
GLY A  13
ALA A  88
VAL A 110
ILE A  90
VAL A  67
 None
 1.48A 2o4lB-3emkA:
undetectable		 2o4lB-3emkA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 216
GLY A  13
 None
 0.89A 2qe6A-3emkA:
5.9		 2qe6A-3emkA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 216
GLY A  13
 None
 0.92A 2qe6B-3emkA:
6.1		 2qe6B-3emkA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ALA A  74
GLU A  75
LEU A 122
ARG A 129
ILE A 135
 None
 1.10A 2qxsA-3emkA:
undetectable		 2qxsA-3emkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ALA A  74
GLU A  75
LEU A 122
ARG A 129
ILE A 135
 None
 1.10A 2qxsB-3emkA:
undetectable		 2qxsB-3emkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 ILE A 140
ALA A 181
GLU A 186
GLY A  17
LEU A  18
 None
 1.27A 2v0mB-3emkA:
undetectable		 2v0mB-3emkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 8 ILE A 137
ASN A 111
SER A 155
SER A 139
 None
 1.06A 2zw9B-3emkA:
5.7		 2zw9B-3emkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 ALA A  74
GLU A  75
LEU A 118
LEU A 122
ARG A 129
 None
 1.34A 3erdB-3emkA:
undetectable		 3erdB-3emkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 5 ASN A 174
ARG A 133
ASN A 178
ALA A 167
 None
 1.46A 3frqA-3emkA:
undetectable		 3frqA-3emkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		4 / 7 ASN A 174
ARG A 133
ASN A 178
ALA A 167
 None
 1.45A 3frqB-3emkA:
1.6		 3frqB-3emkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 0.98A 3n8zA-3emkA:
undetectable		 3n8zA-3emkA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.16A 3pghA-3emkA:
undetectable		 3pghA-3emkA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		6 / 12 LEU A 118
GLY A  13
ALA A  88
VAL A 110
ILE A  90
VAL A  67
 None
 1.49A 4jecA-3emkA:
undetectable		 4jecA-3emkA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.03A 4ph9A-3emkA:
undetectable		 4ph9A-3emkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.02A 4ph9B-3emkA:
undetectable		 4ph9B-3emkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 LEU A 159
ILE A 160
SER A 139
LEU A 112
LEU A 108
 None
 1.24A 5nfjB-3emkA:
undetectable		 5nfjB-3emkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		3 / 3 ARG A  64
LYS A  68
ARG A 129
 None
 1.05A 6c06D-3emkA:
undetectable		 6c06D-3emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3emk GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
melitensis) 		6 / 12 LEU A 118
GLY A  13
ALA A  88
VAL A 110
ILE A  90
VAL A  67
 None
 1.45A 6dilB-3emkA:
undetectable		 6dilB-3emkA:
17.80