SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3emy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 11 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
None
1.20A 1akdA-3emyA:
undetectable
1akdA-3emyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ILE A 268
LEU A 203
PHE A 257
ILE A 207
LEU A 223
None
1.06A 1drfA-3emyA:
undetectable
1drfA-3emyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
None
1.05A 1dz8A-3emyA:
undetectable
1dz8A-3emyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
None
1.04A 1dz8B-3emyA:
undetectable
1dz8B-3emyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
None
1.02A 1dz9B-3emyA:
undetectable
1dz9B-3emyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 1hvyA-3emyA:
undetectable
1hvyA-3emyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.16A 1hvyB-3emyA:
undetectable
1hvyB-3emyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 11 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.11A 1hvyC-3emyA:
undetectable
1hvyC-3emyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 LEU A 272
ASP A 304
GLY A 303
PHE A 302
TYR A  14
None
1.01A 1hvyD-3emyA:
undetectable
1hvyD-3emyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.19A 1i00A-3emyA:
undetectable
1i00A-3emyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.17A 1i00B-3emyA:
undetectable
1i00B-3emyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 8 LEU A 123
VAL A 121
VAL A  96
VAL A  89
None
0.98A 1iwiA-3emyA:
undetectable
1iwiA-3emyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 8 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 1rtsA-3emyA:
undetectable
1rtsA-3emyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 7 ASP A 304
GLY A 303
PHE A 302
TYR A  14
None
0.76A 1rtsB-3emyA:
undetectable
1rtsB-3emyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 GLY A 298
ASP A 224
ILE A 207
GLY A 212
ILE A 213
None
0.83A 1sguB-3emyA:
6.8
1sguB-3emyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 10 GLY A 298
ASP A 224
ILE A 207
GLY A 212
ILE A 213
None
0.92A 1t3rA-3emyA:
6.2
1t3rA-3emyA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 10 GLY A 298
ASP A 224
ILE A 207
GLY A 212
ILE A 213
None
0.91A 1t7iA-3emyA:
6.1
1t7iA-3emyA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 8 LEU A 123
VAL A 121
VAL A  96
VAL A  89
None
0.91A 1t86A-3emyA:
undetectable
1t86A-3emyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 LEU A 321
LEU A 203
SER A 264
VAL A 261
PHE A 192
None
1.38A 1uobA-3emyA:
undetectable
1uobA-3emyA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 PHE A 192
ALA A 194
ILE A 268
ILE A 266
LEU A 223
None
0.96A 1xdkF-3emyA:
undetectable
1xdkF-3emyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 TYR A 165
THR A 216
VAL A 121
GLY A 122
THR A 137
None
1.01A 2a1mA-3emyA:
undetectable
2a1mA-3emyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 5 LEU A 155
ASP A 304
GLY A  34
ALA A 153
None
0.88A 2aohA-3emyA:
6.6
2aohA-3emyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 GLY A 298
ASP A 224
ILE A 207
GLY A 212
ILE A 213
None
0.88A 2b7zB-3emyA:
6.6
2b7zB-3emyA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 GLY A 285
PHE A 284
PRO A 277
THR A 282
None
1.27A 2m2oB-3emyA:
undetectable
2m2oB-3emyA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 5 LEU A 272
ALA A 306
TRP A 323
LEU A 307
None
1.22A 2oaxA-3emyA:
undetectable
2oaxA-3emyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 3 ASP A  37
THR A  45
PRO A  46
None
0.46A 2pynB-3emyA:
6.7
2pynB-3emyA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 3 ASP A  37
THR A  45
PRO A  46
None
0.52A 2q64B-3emyA:
6.6
2q64B-3emyA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 3 ASP A  37
THR A  45
PRO A  46
None
0.47A 2qakB-3emyA:
6.5
2qakB-3emyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 2tsrA-3emyA:
undetectable
2tsrA-3emyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 10 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.10A 2tsrC-3emyA:
undetectable
2tsrC-3emyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.15A 2tsrD-3emyA:
undetectable
2tsrD-3emyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ASP A  32
GLY A  34
SER A  35
TYR A  75
ASP A 215
GLY A 217
None
0.35A 2v0zC-3emyA:
37.7
2v0zC-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
None
0.83A 2v0zC-3emyA:
37.7
2v0zC-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A  32
GLY A  34
ASP A 215
GLY A 217
ILE A 299
None
0.51A 2v0zO-3emyA:
37.8
2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 215
GLY A 217
ASP A  32
GLY A  34
SER A  36
None
0.84A 2v0zO-3emyA:
37.8
2v0zO-3emyA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ILE A 268
LEU A 203
PHE A 257
ILE A 207
LEU A 223
None
1.13A 2w3bB-3emyA:
undetectable
2w3bB-3emyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 LEU A 123
VAL A 121
VAL A  96
VAL A  89
None
0.99A 2z97A-3emyA:
undetectable
2z97A-3emyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 VAL A 174
SER A   1
ILE A  91
LEU A 311
None
0.93A 3kk6A-3emyA:
undetectable
3kk6A-3emyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 PHE A 248
VAL A 246
GLN A 288
VAL A 199
ASN A 234
None
1.31A 3km6B-3emyA:
undetectable
3km6B-3emyA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 10 ASP A   8
ILE A  73
TYR A  75
ILE A 299
THR A 219
None
1.18A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
7 / 10 ASP A   8
ILE A  73
TYR A  75
LEU A 120
ILE A 213
THR A 219
ILE A 297
None
0.56A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ASP A  11
ASP A  32
GLY A  34
PHE A 189
ASP A 215
ILE A 301
None
1.19A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
10 / 12 ASP A  30
ASP A  32
GLY A  34
GLY A  76
ASP A  77
ASP A 114
PHE A 189
ASP A 215
THR A 218
ILE A 301
None
0.43A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ASP A  11
ASP A  32
PHE A 189
ILE A 213
THR A 218
ILE A 301
None
1.38A 3pwwA-3emyA:
51.6
3pwwA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
9 / 12 ASP A  30
ASP A  32
GLY A  76
PHE A 111
LEU A 120
PHE A 189
ILE A 213
THR A 218
ILE A 301
None
0.36A 3pwwA-3emyA:
51.6
3pwwA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A  30
ASP A  32
PHE A 111
LEU A 120
ILE A 213
None
1.08A 3pwwA-3emyA:
51.6
3pwwA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
7 / 12 ILE A  15
ASP A  30
ASP A  32
PHE A 111
LEU A 120
PHE A 189
ILE A 213
None
1.17A 3pwwA-3emyA:
51.6
3pwwA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
8 / 8 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 215
THR A 219
None
0.56A 3pwwA-3emyA:
51.6
3pwwA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE A 301
None
0.28A 3q70A-3emyA:
11.3
3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ASP A  32
GLY A  34
ILE A 117
ASP A 215
THR A 218
ILE A 301
None
1.13A 3q70A-3emyA:
11.3
3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 12 ILE A 213
ASP A 215
GLY A 217
ILE A 297
GLU A  13
ASP A  32
None
1.21A 3q70A-3emyA:
11.3
3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 SER A  35
ILE A  73
TYR A  75
ASP A 114
None
1.00A 3q70A-3emyA:
11.3
3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 SER A  35
ILE A  73
TYR A  75
THR A 219
None
0.36A 3q70A-3emyA:
11.3
3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 4 SER A  79
GLY A  34
GLU A 191
None
0.69A 3raeA-3emyA:
undetectable
3raeC-3emyA:
undetectable
3raeA-3emyA:
20.71
3raeC-3emyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 3 ASP A  37
THR A  45
PRO A  46
None
0.62A 3tkgD-3emyA:
6.5
3tkgD-3emyA:
15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
9 / 12 ASP A  32
GLY A  34
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 114
ASP A 215
ILE A 301
None
0.89A 3tneA-3emyA:
35.7
3tneA-3emyA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 SER A  35
TYR A  75
THR A 218
THR A 219
None
0.28A 3tneA-3emyA:
35.7
3tneA-3emyA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
9 / 12 ASP A  32
GLY A  34
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 114
ASP A 215
ILE A 301
None
0.82A 3tneB-3emyA:
35.8
3tneB-3emyA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 7 SER A  35
TYR A  75
THR A 218
THR A 219
None
0.34A 3tneB-3emyA:
35.8
3tneB-3emyA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 5 SER A 103
GLY A  82
TRP A  39
ASP A  37
None
1.16A 3w9tB-3emyA:
undetectable
3w9tB-3emyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 5 SER A 103
GLY A  82
TRP A  39
ASP A  37
None
1.16A 3w9tC-3emyA:
undetectable
3w9tC-3emyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 5 SER A 103
GLY A  82
TRP A  39
ASP A  37
None
1.16A 3w9tD-3emyA:
undetectable
3w9tD-3emyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 7 ASP A  32
GLY A 119
ILE A 117
THR A 216
None
0.90A 4acaC-3emyA:
undetectable
4acaC-3emyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 4eb4A-3emyA:
undetectable
4eb4A-3emyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.15A 4eb4B-3emyA:
undetectable
4eb4B-3emyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.13A 4eb4C-3emyA:
undetectable
4eb4C-3emyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 10 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.16A 4eb4D-3emyA:
undetectable
4eb4D-3emyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.17A 4iqqA-3emyA:
undetectable
4iqqA-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.19A 4iqqB-3emyA:
undetectable
4iqqB-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.12A 4iqqC-3emyA:
undetectable
4iqqC-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 8 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.15A 4iqqD-3emyA:
undetectable
4iqqD-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 11 GLY A 298
ASP A 224
ILE A 207
GLY A 212
ILE A 213
None
0.88A 4q1xA-3emyA:
6.1
4q1xA-3emyA:
15.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
8 / 9 ASP A  30
ASP A  32
TYR A  75
ASP A  77
SER A  79
PHE A 111
ASP A 114
LEU A 120
None
0.37A 4y4jA-3emyA:
52.0
4y4jA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
6 / 9 ASP A  32
TYR A  75
SER A  79
SER A 108
PHE A 111
LEU A 120
None
1.45A 4y4jA-3emyA:
52.0
4y4jA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 8 PHE A 302
GLY A 303
THR A 193
TYR A 197
None
1.00A 5flcF-3emyA:
undetectable
5flcF-3emyA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 7 ASP A 304
GLY A 303
PHE A 302
TYR A  14
None
0.74A 5h3aA-3emyA:
undetectable
5h3aA-3emyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.19A 5h3aB-3emyA:
undetectable
5h3aB-3emyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
3 / 3 HIS A   5
ASN A   4
ALA A   2
None
0.70A 5n4tB-3emyA:
undetectable
5n4tB-3emyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.18A 5nooA-3emyA:
undetectable
5nooA-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.16A 5nooB-3emyA:
undetectable
5nooB-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 6 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 5nooC-3emyA:
undetectable
5nooC-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 PHE A 125
LEU A 123
TRP A 190
GLY A  34
None
0.88A 5o4yA-3emyA:
undetectable
5o4yA-3emyA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 PHE A 125
LEU A 123
TRP A 190
GLY A  34
THR A 137
None
1.30A 5o4yD-3emyA:
undetectable
5o4yE-3emyA:
undetectable
5o4yD-3emyA:
5.45
5o4yE-3emyA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 6 PHE A 125
LEU A 123
TRP A 190
GLY A  34
None
1.08A 5o4yF-3emyA:
undetectable
5o4yF-3emyA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 12 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.15A 5x5qB-3emyA:
undetectable
5x5qB-3emyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 7 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 5x5qC-3emyA:
undetectable
5x5qC-3emyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 8 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.14A 5x5qD-3emyA:
undetectable
5x5qD-3emyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 8 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.15A 5x5qF-3emyA:
undetectable
5x5qF-3emyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
5 / 9 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.26A 5x66C-3emyA:
undetectable
5x66C-3emyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei)
4 / 8 GLY A 286
LEU A 220
SER A  12
ALA A  10
None
0.99A 5xu8A-3emyA:
undetectable
5xu8A-3emyA:
20.16