SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3enk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 9 LEU A 111
VAL A  63
ILE A  72
VAL A  32
ILE A  33
 None
NAD  A 341 (-3.6A)
None
None
None
 1.18A 1gebA-3enkA:
undetectable		 1gebA-3enkA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		3 / 3 ALA A 258
VAL A 175
TRP A 173
 None
 0.73A 1gmkC-3enkA:
undetectable
1gmkD-3enkA:
undetectable		 1gmkC-3enkA:
8.72
1gmkD-3enkA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 11 LEU A 178
LEU A 260
ARG A 255
LEU A 253
ALA A 248
 None
 1.10A 1h9zA-3enkA:
undetectable		 1h9zA-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		6 / 10 GLY A  11
ALA A  13
ASP A  35
ASP A  62
VAL A  63
ALA A  85
 NAD  A 341 (-3.4A)
NAD  A 341 ( 4.5A)
NAD  A 341 (-2.7A)
NAD  A 341 (-3.6A)
NAD  A 341 (-3.6A)
NAD  A 341 (-3.6A)
 0.55A 1uayB-3enkA:
18.6		 1uayB-3enkA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 12 TYR A 180
ALA A 176
ALA A 252
ILE A 123
HIS A 246
 NAD  A 341 (-4.5A)
None
None
None
None
 1.12A 1ve3A-3enkA:
7.5		 1ve3A-3enkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		6 / 12 GLY A  11
GLY A  14
HIS A  19
THR A  20
ASP A  35
THR A  61
 NAD  A 341 (-3.4A)
NAD  A 341 (-3.3A)
None
None
NAD  A 341 (-2.7A)
None
 1.44A 2gluA-3enkA:
6.9		 2gluA-3enkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 4 LEU A  37
ILE A  45
ILE A  33
ALA A  34
 None
 0.84A 2i30A-3enkA:
undetectable		 2i30A-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 4 LEU A 178
ARG A 255
LEU A 253
ALA A 248
 None
 1.09A 3b9mA-3enkA:
undetectable		 3b9mA-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 9 VAL A  31
ILE A  33
GLY A  17
ILE A  16
ILE A   7
 None
None
None
NAD  A 341 (-3.9A)
None
 1.04A 3el0B-3enkA:
undetectable		 3el0B-3enkA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 5 ASN A 334
ARG A  47
HIS A  19
ALA A 186
 None
 1.09A 3frqA-3enkA:
undetectable		 3frqA-3enkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 7 ASN A 334
ARG A  47
HIS A  19
ALA A 186
 None
 1.10A 3frqB-3enkA:
undetectable		 3frqB-3enkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 6 VAL A 124
MET A 115
ILE A 247
ILE A  82
 None
 0.97A 3gcsA-3enkA:
undetectable		 3gcsA-3enkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 218
VAL A 207
MET A 204
VAL A 220
 None
None
None
UPG  A 342 (-3.7A)
 1.09A 3soaA-3enkA:
undetectable		 3soaA-3enkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		3 / 3 LEU A 109
GLU A  66
SER A 107
 None
None
NAD  A 341 ( 4.8A)
 0.67A 4ccqA-3enkA:
5.1		 4ccqA-3enkA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 10 ILE A  78
ILE A   7
ALA A  81
THR A  10
VAL A  63
 None
None
None
None
NAD  A 341 (-3.6A)
 1.40A 4kq8A-3enkA:
undetectable		 4kq8A-3enkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 12 ARG A 164
ALA A 308
TYR A 132
LEU A 146
GLY A 153
 None
 1.25A 4l9qA-3enkA:
undetectable		 4l9qA-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		3 / 3 THR A 227
ASN A 182
PHE A 181
 None
UPG  A 342 (-3.3A)
None
 0.82A 4pd9A-3enkA:
undetectable		 4pd9A-3enkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 11 GLY A  11
GLY A  12
THR A  20
ASP A  35
ASP A  62
 NAD  A 341 (-3.4A)
None
None
NAD  A 341 (-2.7A)
NAD  A 341 (-3.6A)
 0.80A 4pghA-3enkA:
5.8		 4pghA-3enkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A  11
GLY A  12
THR A  20
ASP A  35
ASP A  62
 NAD  A 341 (-3.4A)
None
None
NAD  A 341 (-2.7A)
NAD  A 341 (-3.6A)
 1.13A 4pghD-3enkA:
6.2		 4pghD-3enkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 4 VAL A 131
ALA A 148
ASN A 150
GLN A 154
 None
None
UPG  A 342 ( 4.3A)
None
 1.32A 4zgfA-3enkA:
undetectable		 4zgfA-3enkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 6 PRO A 135
GLY A 133
TYR A 132
VAL A 299
 None
 0.89A 5x80A-3enkA:
undetectable
5x80B-3enkA:
undetectable		 5x80A-3enkA:
20.17
5x80B-3enkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 7 VAL A 299
PRO A 135
GLY A 133
TYR A 132
 None
 0.98A 5x80C-3enkA:
undetectable
5x80D-3enkA:
undetectable		 5x80C-3enkA:
20.17
5x80D-3enkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 5 PRO A 226
GLY A 230
TYR A 225
VAL A 233
 None
 1.27A 5x80C-3enkA:
undetectable
5x80D-3enkA:
undetectable		 5x80C-3enkA:
20.17
5x80D-3enkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		3 / 3 ALA A 129
VAL A  90
TYR A 152
 None
None
NAD  A 341 ( 4.5A)
 0.55A 5zmqH-3enkA:
undetectable		 5zmqH-3enkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		5 / 9 ALA A  21
ALA A  13
GLY A  17
ALA A  34
GLY A  11
 None
NAD  A 341 ( 4.5A)
None
None
NAD  A 341 (-3.4A)
 0.93A 6bklE-3enkA:
undetectable
6bklF-3enkA:
undetectable
6bklG-3enkA:
undetectable
6bklH-3enkA:
undetectable		 6bklE-3enkA:
7.84
6bklF-3enkA:
7.84
6bklG-3enkA:
7.84
6bklH-3enkA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 8 GLY A 153
GLN A 154
THR A 155
SER A 128
 None
None
None
UPG  A 342 (-2.7A)
 1.00A 6eqpA-3enkA:
3.2		 6eqpA-3enkA:
13.21