SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 7 TYR A 128
HIS A 107
THR A 278
ASN A 286
 MG  A 600 (-4.8A)
MG  A 600 (-3.9A)
None
None
 1.35A 1afsA-3enoA:
undetectable		 1afsA-3enoA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 7 TYR A 128
HIS A 107
THR A 278
ASN A 286
 MG  A 600 (-4.8A)
MG  A 600 (-3.9A)
None
None
 1.35A 1afsB-3enoA:
undetectable		 1afsB-3enoA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 9 THR A  87
GLY A   8
GLY A  73
PHE A  74
GLY A   5
 None
 1.01A 1jhoA-3enoA:
2.6		 1jhoA-3enoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 9 THR A  87
GLY A   8
GLY A  73
PHE A  74
GLY A   5
 None
 1.04A 1l5kA-3enoA:
2.0		 1l5kA-3enoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 9 THR A  87
GLY A   8
GLY A  73
PHE A  74
GLY A   5
 None
 1.04A 1l5lA-3enoA:
2.4		 1l5lA-3enoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 9 THR A  87
GLY A   8
GLY A  73
PHE A  74
GLY A   5
 None
 1.04A 1l5mA-3enoA:
2.7		 1l5mA-3enoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A   6
GLY A 287
ILE A  94
VAL A   3
GLY A  16
 None
 0.87A 1uakA-3enoA:
undetectable		 1uakA-3enoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 282
ALA A 291
GLY A 287
ALA A 294
ILE A  17
 None
 1.19A 1ve3A-3enoA:
undetectable		 1ve3A-3enoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 SER A 300
GLU A 113
ASP A 123
 None
 0.69A 2avdB-3enoA:
undetectable		 2avdB-3enoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 10 ASP A 285
SER A  56
ILE A  55
LEU A  80
THR A   9
 MG  A 600 (-3.1A)
None
None
None
None
 1.22A 2v0mA-3enoA:
undetectable		 2v0mA-3enoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 11 ALA A  91
ALA A  88
GLY A  77
GLY A  73
ILE A 102
 None
 1.17A 2x1lA-3enoA:
2.2		 2x1lA-3enoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 MET A  26
VAL A 118
ASP A 279
GLY A  16
ILE A 288
 None
 1.42A 3a65A-3enoA:
undetectable		 3a65A-3enoA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 295
LEU A 296
ALA A 293
GLU A 113
GLY A  16
 None
 1.01A 3olsA-3enoA:
undetectable		 3olsA-3enoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 295
LEU A 296
ALA A 293
GLU A 113
GLY A  16
 None
 0.98A 3q95B-3enoA:
undetectable		 3q95B-3enoA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 288
GLY A 287
VAL A 118
ARG A 261
 None
 0.88A 4acbB-3enoA:
2.8
4acbC-3enoA:
undetectable		 4acbB-3enoA:
23.01
4acbC-3enoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 318
ARG A 316
ASP A 321
 None
 0.86A 4fp9A-3enoA:
undetectable		 4fp9A-3enoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 295
LEU A 296
ALA A 293
GLU A 113
GLY A  16
 None
 1.01A 4pxmA-3enoA:
undetectable		 4pxmA-3enoA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 9 LEU A   6
SER A  75
THR A  87
ILE A  51
VAL A  54
 None
 1.24A 6ef6A-3enoA:
undetectable		 6ef6A-3enoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 LYS A 245
VAL A 125
ASP A 123
 None
 0.58A 6fgdA-3enoA:
undetectable		 6fgdA-3enoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 7 ARG A 274
TYR A 276
GLU A 247
ASP A 246
 None
 1.19A 6mn5E-3enoA:
undetectable		 6mn5E-3enoA:
13.17