SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 11 THR A 542
LEU A 540
VAL A 653
GLY A 652
VAL A 682
 None
 1.26A 1akdA-3eo3A:
undetectable		 1akdA-3eo3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 11 ILE A 541
ASN A 516
LEU A 567
GLY A 568
ALA A 564
 None
 1.12A 1ju6A-3eo3A:
undetectable		 1ju6A-3eo3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 10 ILE A 541
ASN A 516
LEU A 567
GLY A 568
ALA A 564
 None
 1.12A 1ju6C-3eo3A:
undetectable		 1ju6C-3eo3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 11 ILE A 541
ASN A 516
LEU A 567
GLY A 568
ALA A 564
 None
 1.13A 1ju6D-3eo3A:
undetectable		 1ju6D-3eo3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 PRO A 704
GLY A 708
ALA A 521
VAL A 713
ALA A 411
 UNX  A   2 ( 3.9A)
None
None
None
None
 1.13A 1sg9C-3eo3A:
undetectable		 1sg9C-3eo3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 9 THR A 542
LEU A 540
VAL A 653
GLY A 652
ILE A 678
 None
 1.14A 2a1oB-3eo3A:
undetectable		 2a1oB-3eo3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.75A 2iwkA-3eo3A:
undetectable		 2iwkA-3eo3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.74A 2iwkB-3eo3A:
undetectable		 2iwkB-3eo3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 THR A 542
ASP A 517
ASN A 516
ASP A 515
 None
 0.88A 2okcA-3eo3A:
undetectable		 2okcA-3eo3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.70A 3dtuB-3eo3A:
undetectable		 3dtuB-3eo3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.68A 3dtuD-3eo3A:
undetectable		 3dtuD-3eo3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 LEU A 707
ALA A 521
GLY A 529
LEU A 523
SER A 711
 None
 1.34A 3gyqA-3eo3A:
undetectable
3gyqB-3eo3A:
undetectable		 3gyqA-3eo3A:
22.03
3gyqB-3eo3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 LYS A 433
LEU A 706
LEU A 410
ILE A 430
SER A 408
 None
 1.45A 3iltB-3eo3A:
undetectable
3iltE-3eo3A:
undetectable		 3iltB-3eo3A:
19.72
3iltE-3eo3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 10 ILE A 430
SER A 408
LYS A 433
LEU A 706
LEU A 410
 None
 1.42A 3iltB-3eo3A:
undetectable
3iltE-3eo3A:
undetectable		 3iltB-3eo3A:
19.72
3iltE-3eo3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 LEU A 625
ALA A 624
LEU A 671
ILE A 678
GLY A 646
 None
 1.06A 3q95B-3eo3A:
undetectable		 3q95B-3eo3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		6 / 12 LEU A 504
ILE A 449
ASP A 515
GLY A 471
VAL A 470
GLY A 518
 None
 1.24A 4an2A-3eo3A:
undetectable		 4an2A-3eo3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 ASN A 516
ALA A 524
GLY A 708
MET A 712
GLY A 529
 None
 1.22A 4obwA-3eo3A:
undetectable		 4obwA-3eo3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 ALA A 522
GLY A 549
GLY A 548
ILE A 666
GLY A 531
 None
 1.07A 4obwB-3eo3A:
undetectable		 4obwB-3eo3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 11 LEU A 625
ALA A 624
LEU A 671
ILE A 678
GLY A 646
 None
 1.10A 4pxmB-3eo3A:
undetectable		 4pxmB-3eo3A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 LEU A 625
ALA A 624
LEU A 671
ILE A 678
GLY A 646
 None
 1.04A 5gtrA-3eo3A:
undetectable		 5gtrA-3eo3A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		6 / 12 LEU A 714
GLY A 708
ALA A 709
VAL A 470
ILE A 430
SER A 408
 None
 1.50A 5t2zB-3eo3A:
undetectable		 5t2zB-3eo3A:
15.32