SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 7 LEU A 338
ILE A 310
THR A 341
MET A 315
 None
 1.24A 1kglA-3eoeA:
undetectable		 1kglA-3eoeA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		3 / 3 MET A 363
ASN A 335
GLN A 295
 None
 1.03A 1xoqB-3eoeA:
undetectable		 1xoqB-3eoeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		5 / 7 VAL A 491
ILE A 426
ALA A 398
VAL A 397
GLY A 493
 None
 1.35A 2xrzB-3eoeA:
undetectable		 2xrzB-3eoeA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 7 GLN A 150
ILE A 128
TYR A 145
CYH A 143
 None
 1.41A 2xz5D-3eoeA:
undetectable
2xz5E-3eoeA:
undetectable		 2xz5D-3eoeA:
17.95
2xz5E-3eoeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 6 VAL A 167
ILE A 141
ILE A 158
LEU A 159
 None
 0.78A 3hegA-3eoeA:
undetectable		 3hegA-3eoeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		6 / 12 LEU A 269
ALA A 233
ASP A 234
ASP A 235
VAL A 230
ILE A 268
 None
 1.45A 3jw2A-3eoeA:
undetectable		 3jw2A-3eoeA:
12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		8 / 10 THR A  43
PRO A  46
ARG A  66
ASN A  68
HIS A  71
GLY A  72
GLY A 348
ALA A 351
 None
 0.24A 3pp7B-3eoeA:
54.6		 3pp7B-3eoeA:
42.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 5 LEU A 214
LEU A 243
GLY A 244
GLY A 247
 None
 0.70A 3si7C-3eoeA:
undetectable
3si7D-3eoeA:
0.9		 3si7C-3eoeA:
20.27
3si7D-3eoeA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 6 MET A 193
PRO A 149
GLN A 150
TYR A 145
 None
 1.48A 3vkxA-3eoeA:
undetectable		 3vkxA-3eoeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 8 ASP A 162
ASP A 101
ASN A 192
ASP A 281
 None
 1.12A 4feuD-3eoeA:
undetectable		 4feuD-3eoeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		5 / 9 ALA A 272
ILE A 256
ILE A 310
ILE A 239
VAL A 236
 None
 1.11A 4nptA-3eoeA:
undetectable		 4nptA-3eoeA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		5 / 12 ALA A 312
SER A 318
THR A 326
GLU A 349
SER A 347
 None
 1.22A 5hfjE-3eoeA:
undetectable		 5hfjE-3eoeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 6 LEU A 338
ILE A 310
THR A 341
MET A 315
 None
 1.27A 5ljeA-3eoeA:
undetectable		 5ljeA-3eoeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		3 / 3 CYH A  65
MET A  62
ASN A  63
 None
 1.03A 5qh8A-3eoeA:
undetectable		 5qh8A-3eoeA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3eoe PYRUVATE KINASE
(Toxoplasma
gondii) 		4 / 7 ILE A 412
LEU A 436
MET A 457
LEU A 438
 None
 0.80A 5u4sA-3eoeA:
undetectable		 5u4sA-3eoeA:
20.90