SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 8 LEU A 130
MET A  66
GLU A  69
ALA A  70
VAL A  73
 FMN  A 300 (-4.6A)
FMN  A 300 (-4.7A)
None
None
None
 1.24A 1a29A-3eofA:
undetectable		 1a29A-3eofA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 10 ARG A  49
LEU A  74
LEU A  27
ALA A 120
GLY A 124
 None
 1.18A 1cmcA-3eofA:
undetectable
1cmcB-3eofA:
undetectable		 1cmcA-3eofA:
18.07
1cmcB-3eofA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 10 ALA A 113
LEU A  28
LEU A 119
ALA A 120
PHE A  32
 None
 1.21A 1g5yC-3eofA:
undetectable		 1g5yC-3eofA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 12 ALA A 120
GLY A 124
ARG A  49
LEU A  74
LEU A  27
 None
 1.21A 1mj2A-3eofA:
undetectable
1mj2B-3eofA:
undetectable		 1mj2A-3eofA:
16.87
1mj2B-3eofA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 12 ALA A 120
GLY A 124
ARG A  49
LEU A  74
LEU A  27
 None
 1.20A 1mj2C-3eofA:
undetectable
1mj2D-3eofA:
undetectable		 1mj2C-3eofA:
16.87
1mj2D-3eofA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 12 ALA A 120
GLY A 124
ARG A  49
LEU A  74
LEU A  27
 None
 1.20A 1mjoC-3eofA:
undetectable
1mjoD-3eofA:
undetectable		 1mjoC-3eofA:
16.87
1mjoD-3eofA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 12 THR A  48
VAL A  72
VAL A 158
PHE A  76
PHE A 116
 None
 1.46A 2y03B-3eofA:
undetectable		 2y03B-3eofA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 12 THR A  48
VAL A  72
VAL A 158
PHE A  76
PHE A 116
 None
 1.43A 2y04B-3eofA:
undetectable		 2y04B-3eofA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 10 THR A  48
LEU A 144
THR A 155
VAL A  67
VAL A  73
 None
 1.17A 3lxiA-3eofA:
undetectable		 3lxiA-3eofA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		5 / 11 THR A  48
LEU A 144
THR A 155
VAL A  67
VAL A  73
 None
 1.19A 3lxiB-3eofA:
undetectable		 3lxiB-3eofA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 7 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.76A 4eq4A-3eofA:
2.2		 4eq4A-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 8 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.67A 4eq4B-3eofA:
undetectable		 4eq4B-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 7 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.73A 4eqlA-3eofA:
undetectable		 4eqlA-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 7 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.70A 4eqlB-3eofA:
undetectable		 4eqlB-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		3 / 3 LEU A 200
PRO A 201
ARG A   9
 None
 0.60A 4klrB-3eofA:
undetectable		 4klrB-3eofA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 7 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.74A 4l39B-3eofA:
undetectable		 4l39B-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3eof PUTATIVE
OXIDOREDUCTASE
(Bacteroides
fragilis) 		4 / 8 LEU A  27
ILE A 127
VAL A   5
THR A   4
 None
 0.91A 4ma7A-3eofA:
undetectable		 4ma7A-3eofA:
16.05