SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eoq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 10 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.18A 1fkoA-3eoqA:
3.6		 1fkoA-3eoqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 LEU A 196
VAL A  24
GLY A 189
LEU A  99
 None
 0.88A 1jlbA-3eoqA:
4.0		 1jlbA-3eoqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 9 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.18A 1lwfA-3eoqA:
3.4		 1lwfA-3eoqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.18A 1q23A-3eoqA:
undetectable		 1q23A-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.05A 1q23F-3eoqA:
undetectable		 1q23F-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.23A 1q23K-3eoqA:
undetectable		 1q23K-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 10 THR A 158
GLY A  43
VAL A 155
GLU A 139
SER A 161
 None
 1.27A 1z35A-3eoqA:
undetectable		 1z35A-3eoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 11 LEU A 314
VAL A 275
ALA A 280
SER A 284
LEU A 270
 None
 1.36A 2c12F-3eoqA:
undetectable		 2c12F-3eoqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 12 ALA A  77
HIS A  50
GLU A  49
HIS A  46
GLU A 125
 None
 0.68A 2c6nA-3eoqA:
2.5		 2c6nA-3eoqA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 10 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.16A 2hnyA-3eoqA:
3.4		 2hnyA-3eoqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 12 LEU A 356
LEU A 353
ILE A  14
PRO A  92
VAL A 191
 None
 1.13A 2pnjA-3eoqA:
undetectable		 2pnjA-3eoqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
GLU A  81
LEU A 151
SER A  80
 None
 1.07A 2q0iA-3eoqA:
undetectable		 2q0iA-3eoqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 12 ARG A 352
TYR A 366
HIS A 355
VAL A 372
GLU A 370
 None
 1.42A 2qeoA-3eoqA:
undetectable		 2qeoA-3eoqA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 12 PHE A  53
ALA A 187
LEU A 196
ALA A 200
THR A 204
 None
 0.81A 2ve3A-3eoqA:
undetectable		 2ve3A-3eoqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 10 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.18A 3lp1A-3eoqA:
2.9		 3lp1A-3eoqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 12 GLY A 169
ARG A 214
ARG A 177
ALA A  34
ASP A  36
 None
 1.10A 3sugA-3eoqA:
undetectable		 3sugA-3eoqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 11 THR A 158
GLY A  43
VAL A 155
GLU A 139
SER A 161
 None
 1.13A 3uawA-3eoqA:
undetectable		 3uawA-3eoqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		3 / 3 ARG A 176
GLU A  37
THR A  38
 None
 0.91A 3v4tA-3eoqA:
undetectable		 3v4tA-3eoqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 LEU A 196
VAL A  24
VAL A  17
LEU A  99
 None
 1.09A 3v81C-3eoqA:
3.5		 3v81C-3eoqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 PHE A  68
ALA A  77
LEU A 106
LEU A 105
 None
 0.88A 4ejgB-3eoqA:
undetectable		 4ejgB-3eoqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 7 PHE A  68
ALA A  77
LEU A 106
LEU A 105
 None
 0.86A 4ejgC-3eoqA:
undetectable		 4ejgC-3eoqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 7 HIS A 297
GLY A 286
TYR A 299
ALA A 240
 None
 0.93A 4hyfA-3eoqA:
undetectable		 4hyfA-3eoqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 LEU A 196
VAL A  24
VAL A  17
LEU A  99
 None
 1.12A 4q0bA-3eoqA:
4.7		 4q0bA-3eoqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 10 TYR A 366
LEU A 356
LEU A 196
ALA A  95
GLY A 189
 None
 1.19A 4rn6A-3eoqA:
undetectable		 4rn6A-3eoqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		5 / 11 LEU A 196
VAL A  24
VAL A  17
GLY A 189
TYR A  96
 None
 1.47A 5hbmA-3eoqA:
2.9		 5hbmA-3eoqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 8 LEU A 241
ALA A 290
VAL A 239
HIS A 149
 None
 0.89A 5nu7A-3eoqA:
undetectable		 5nu7A-3eoqA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 6 GLU A 227
LEU A 402
LYS A 307
LEU A 311
 None
 1.00A 5yvnA-3eoqA:
undetectable		 5yvnA-3eoqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		3 / 3 ARG A 352
GLY A 346
GLU A 347
 None
 0.40A 6fgdA-3eoqA:
undetectable		 6fgdA-3eoqA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3eoq PUTATIVE ZINC
PROTEASE
(Thermus
thermophilus) 		4 / 6 MET A 350
ALA A  95
LEU A  26
ALA A 187
 None
 1.14A 6fosB-3eoqA:
undetectable		 6fosB-3eoqA:
10.25