SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ep7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP A 100
LYS B  27
ARG B  20
 None
 1.15A 1ra8A-3ep7A:
undetectable		 1ra8A-3ep7A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 LEU A 180
ILE A 268
LEU A 177
THR A 176
LEU A 284
 None
 1.07A 2bdmA-3ep7A:
undetectable		 2bdmA-3ep7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Homo
sapiens) 		4 / 6 PHE B  18
LEU A  91
LEU A  97
ALA A  98
 None
 0.98A 2vcvB-3ep7B:
undetectable		 2vcvB-3ep7B:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER A  73
GLN B  60
PHE A  71
 None
 0.81A 3g4lC-3ep7A:
undetectable		 3g4lC-3ep7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 TYR A 158
ILE A  78
LEU A  79
LYS A  80
 None
 1.29A 3sueC-3ep7A:
undetectable		 3sueC-3ep7A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL B  64
ALA B  62
PHE A 255
VAL A 253
THR B  55
 PYR  A  68 (-3.6A)
None
None
None
None
 1.19A 4eckA-3ep7B:
undetectable		 4eckA-3ep7B:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 VAL A 286
LEU A 284
ILE A 268
GLN A 300
 None
 0.86A 4ma7A-3ep7A:
undetectable		 4ma7A-3ep7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 VAL A 286
LEU A 284
TYR A 264
ILE A 268
 None
 0.92A 4ma7A-3ep7A:
undetectable		 4ma7A-3ep7A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 VAL A 274
PHE A 275
ILE A 242
THR A 257
LEU A 212
 None
 1.02A 6h1lB-3ep7A:
undetectable		 6h1lB-3ep7A:
21.68