SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3epd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 11 SER 2  21
LEU 2  16
THR 2 206
ILE 2 207
ILE 2 252
 None
 1.13A 1pkvA-3epd2:
undetectable
1pkvB-3epd2:
undetectable		 1pkvA-3epd2:
17.05
1pkvB-3epd2:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 11 ILE 2 252
SER 2  21
LEU 2  16
THR 2 206
ILE 2 207
 None
 1.16A 1pkvA-3epd2:
undetectable
1pkvB-3epd2:
undetectable		 1pkvA-3epd2:
17.05
1pkvB-3epd2:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 11 VAL 2 208
SER 2  21
LEU 2  16
THR 2 206
ILE 2 207
 None
 1.23A 1pkvA-3epd2:
undetectable
1pkvB-3epd2:
undetectable		 1pkvA-3epd2:
17.05
1pkvB-3epd2:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3epd PROTEIN VP1
(Enterovirus
C) 		4 / 5 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.99A 1tt6B-3epd1:
1.5		 1tt6B-3epd1:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3epd PROTEIN VP1
(Enterovirus
C) 		4 / 6 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.89A 1tz8C-3epd1:
undetectable
1tz8D-3epd1:
undetectable		 1tz8C-3epd1:
21.51
1tz8D-3epd1:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		4 / 8 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
 None
 0.92A 1ya4A-3epd2:
undetectable		 1ya4A-3epd2:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		4 / 7 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
 None
 0.93A 1ya4B-3epd2:
undetectable		 1ya4B-3epd2:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3epd PROTEIN VP1
PROTEIN VP2
(Enterovirus
C) 		3 / 3 TRP 2 226
THR 1 126
TYR 1 127
 None
 1.23A 2a3aA-3epd2:
undetectable		 2a3aA-3epd2:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3epd PROTEIN VP1
PROTEIN VP2
(Enterovirus
C) 		3 / 3 TRP 2 226
THR 1 126
TYR 1 127
 None
 1.27A 2a3bA-3epd2:
undetectable		 2a3bA-3epd2:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3epd PROTEIN VP1
PROTEIN VP2
(Enterovirus
C;
Enterovirus
C) 		5 / 12 ILE 2 127
ALA 2 133
CYH 2 182
VAL 2 184
TYR 1 280
 None
 1.12A 2g72B-3epd2:
undetectable		 2g72B-3epd2:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3epd PROTEIN VP2
POLIOVIRUS RECEPTOR
(Enterovirus
C;
Homo
sapiens) 		3 / 3 GLY R 100
ARG R  98
TYR 2 141
 None
 0.77A 2opxA-3epdR:
undetectable		 2opxA-3epdR:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3epd POLIOVIRUS RECEPTOR
(Homo
sapiens) 		4 / 8 VAL R  53
PRO R  54
VAL R  31
ARG R 133
 None
 0.90A 2v32C-3epdR:
undetectable
2v32D-3epdR:
undetectable		 2v32C-3epdR:
20.65
2v32D-3epdR:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 12 ALA 2 126
VAL 2 108
GLY 2 123
ILE 2 196
ILE 2 207
 None
 1.01A 3d1zA-3epd2:
undetectable		 3d1zA-3epd2:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		4 / 5 TYR 2 130
ALA 2  85
ALA 2 147
TYR 2 144
 None
 1.07A 3d91A-3epd2:
undetectable		 3d91A-3epd2:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 9 ALA 2 126
VAL 2 108
GLY 2 123
ILE 2 196
ILE 2 207
 None
 1.05A 3ekvB-3epd2:
undetectable		 3ekvB-3epd2:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3epd PROTEIN VP2
POLIOVIRUS RECEPTOR
(Enterovirus
C;
Homo
sapiens) 		4 / 7 LYS 2 162
TYR 2 141
HIS R  60
ALA R 101
 None
 1.13A 3frqB-3epd2:
undetectable		 3frqB-3epd2:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		3 / 3 PRO 2  53
THR 2  54
LEU 2 262
 None
 0.49A 3ttrA-3epd2:
undetectable		 3ttrA-3epd2:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3epd PROTEIN VP2
(Enterovirus
C) 		4 / 6 ASN 2  30
ALA 2  28
THR 2  25
LEU 2  16
 None
 1.05A 4ejgD-3epd2:
undetectable		 4ejgD-3epd2:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 12 ALA 2 126
VAL 2 108
GLY 2 123
ILE 2 196
ILE 2 207
 None
 1.02A 4jecB-3epd2:
undetectable		 4jecB-3epd2:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3epd PROTEIN VP1
(Enterovirus
C) 		4 / 6 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.96A 4pwjA-3epd1:
undetectable		 4pwjA-3epd1:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 10 ALA 2 126
VAL 2 108
GLY 2 123
ILE 2 196
ILE 2 207
 None
 1.10A 4q1wB-3epd2:
undetectable		 4q1wB-3epd2:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3epd PROTEIN VP2
(Enterovirus
C) 		3 / 3 ASP 2  57
LEU 2  18
GLY 2  19
 None
 0.46A 4xmfA-3epd2:
undetectable		 4xmfA-3epd2:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3epd PROTEIN VP2
(Enterovirus
C) 		3 / 3 ALA 2 253
TYR 2  64
PRO 2  56
 None
 0.70A 4zdyA-3epd2:
undetectable		 4zdyA-3epd2:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		4 / 4 VAL 2 110
ALA 2 205
ASN 2 202
GLN 2 195
 None
 1.47A 4zgfA-3epd2:
undetectable		 4zgfA-3epd2:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3epd POLIOVIRUS RECEPTOR
(Homo
sapiens) 		4 / 7 THR R  65
ALA R  67
SER R 120
THR R 122
 None
 0.90A 5bojB-3epdR:
undetectable		 5bojB-3epdR:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3epd POLIOVIRUS RECEPTOR
(Homo
sapiens) 		4 / 8 ASN R 147
PHE R 228
GLU R 226
THR R 235
 None
 1.40A 5hqaA-3epdR:
undetectable		 5hqaA-3epdR:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 12 ALA 2 126
VAL 2 108
GLY 2 123
ILE 2 196
ILE 2 207
 None
 1.06A 5kqyA-3epd2:
undetectable		 5kqyA-3epd2:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 10 VAL 2 108
ILE 2 252
LEU 2  86
GLY 2 227
ALA 2 126
 None
 0.98A 5mxbA-3epd2:
undetectable		 5mxbA-3epd2:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3epd PROTEIN VP2
(Enterovirus
C) 		5 / 10 VAL 2 124
GLY 2 123
ALA 2 205
ASN 2 198
ASN 2 202
 None
 1.11A 5x6yB-3epd2:
undetectable		 5x6yB-3epd2:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3epd PROTEIN VP2
(Enterovirus
C) 		3 / 3 TYR 2 192
ALA 2 229
LEU 2 180
 None
 0.61A 6d9kF-3epd2:
undetectable		 6d9kF-3epd2:
16.69