SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3epj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 207
LEU A 357
LEU A 356
LEU A 304
ILE A 305
 None
 1.21A 1fmlA-3epjA:
6.6		 1fmlA-3epjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 207
LEU A 357
LEU A 356
LEU A 304
ILE A 305
 None
 1.21A 1fmlB-3epjA:
6.6		 1fmlB-3epjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 315
LEU A 204
LEU A  34
ILE A 332
ALA A 333
 None
 1.07A 1ha2A-3epjA:
undetectable		 1ha2A-3epjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.00A 1rxcC-3epjA:
2.7		 1rxcC-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.01A 1rxcD-3epjA:
2.8		 1rxcD-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.08A 1rxcF-3epjA:
2.8		 1rxcF-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.08A 1rxcL-3epjA:
2.9		 1rxcL-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 115
THR A 112
VAL A  50
VAL A 257
VAL A 254
 A  E  36 ( 4.9A)
A  E  37 ( 2.5A)
None
A  E  37 ( 4.3A)
None
 1.49A 1t86A-3epjA:
undetectable		 1t86A-3epjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 115
THR A 112
VAL A  50
VAL A 257
VAL A 254
 A  E  36 ( 4.9A)
A  E  37 ( 2.5A)
None
A  E  37 ( 4.3A)
None
 1.49A 1t86B-3epjA:
undetectable		 1t86B-3epjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 335
LEU A  34
LEU A 304
HIS A 113
VAL A  18
 None
 1.30A 1uobA-3epjA:
undetectable		 1uobA-3epjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 221
ILE A 258
ILE A 233
LEU A 225
PHE A 263
 None
A  E  37 ( 3.9A)
None
None
None
 1.09A 1z11C-3epjA:
undetectable		 1z11C-3epjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 221
ILE A 258
ILE A 233
LEU A 225
PHE A 263
 None
A  E  37 ( 3.9A)
None
None
None
 1.07A 1z11D-3epjA:
undetectable		 1z11D-3epjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  34
LEU A 315
ILE A 334
ALA A 333
 None
 0.67A 2i2zA-3epjA:
undetectable		 2i2zA-3epjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.11A 3kvvA-3epjA:
2.8		 3kvvA-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.07A 3kvvB-3epjA:
2.9		 3kvvB-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.11A 3kvvC-3epjA:
undetectable		 3kvvC-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.11A 3kvvD-3epjA:
3.5		 3kvvD-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.11A 3kvvF-3epjA:
2.6		 3kvvF-3epjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 300
LEU A 304
SER A  45
SER A  31
 None
 1.00A 3r9vA-3epjA:
undetectable
3r9vB-3epjA:
undetectable		 3r9vA-3epjA:
21.84
3r9vB-3epjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 110
GLN A  49
MET A  74
ILE A  19
 None
 1.08A 4e1vF-3epjA:
undetectable		 4e1vF-3epjA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 185
PRO A 186
SER A 187
 None
 0.41A 4k50I-3epjA:
undetectable		 4k50I-3epjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 218
LEU A 217
PHE A 214
 None
 0.66A 4pthA-3epjA:
3.3		 4pthA-3epjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 236
LEU A 264
PHE A 260
ILE A 258
 None
None
None
A  E  37 ( 3.9A)
 1.17A 4y4dA-3epjA:
undetectable		 4y4dA-3epjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 230
VAL A 221
ASP A 222
 None
 0.71A 4y8wC-3epjA:
undetectable		 4y8wC-3epjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 114
LYS A 122
HIS A  86
TYR A 164
 A  E  36 ( 3.4A)
U  E  33 ( 4.7A)
G  E  34 ( 4.3A)
U  E  33 ( 4.4A)
 1.47A 5dlvB-3epjA:
undetectable		 5dlvB-3epjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 316
TRP A 323
ALA A 317
LEU A 320
 None
MG  A   5 ( 4.2A)
None
None
 1.05A 5nwvA-3epjA:
undetectable		 5nwvA-3epjA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3epj TRNA
ISOPENTENYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  77
TYR A  51
GLU A  91
 None
 0.95A 5zmqD-3epjA:
undetectable
5zmqE-3epjA:
undetectable		 5zmqD-3epjA:
19.05
5zmqE-3epjA:
8.89