SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3epr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 5 TYR A  17
VAL A  54
VAL A  43
ASP A  11
 None
None
None
NA  A 266 (-2.7A)
 1.46A 1dz6B-3eprA:
undetectable		 1dz6B-3eprA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 6 ASP A 207
ASN A 208
ASP A  11
TYR A  17
 NA  A 266 (-2.6A)
GOL  A 265 (-3.6A)
NA  A 266 (-2.7A)
None
 1.07A 1hpkA-3eprA:
undetectable		 1hpkA-3eprA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 5 PHE A  29
LEU A 247
VAL A 226
VAL A 203
 None
 1.22A 1t88B-3eprA:
undetectable		 1t88B-3eprA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		3 / 3 PRO A  66
LEU A  67
GLN A  55
 None
 0.55A 3hznG-3eprA:
undetectable
3hznH-3eprA:
undetectable		 3hznG-3eprA:
20.22
3hznH-3eprA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 4 PHE A 230
TYR A 209
ILE A  16
LEU A  12
 GOL  A 265 (-3.7A)
None
None
None
 1.38A 3sudA-3eprA:
undetectable		 3sudA-3eprA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 5 PHE A 230
TYR A 209
ILE A  16
LEU A  12
 GOL  A 265 (-3.7A)
None
None
None
 1.35A 3sueC-3eprA:
undetectable		 3sueC-3eprA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		4 / 5 PHE A  29
LEU A 247
VAL A 226
VAL A 203
 None
 1.21A 4l49A-3eprA:
undetectable		 4l49A-3eprA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
agalactiae) 		5 / 12 ALA A  25
ASP A 207
LEU A  12
LEU A  58
ILE A  30
 None
NA  A 266 (-2.6A)
None
None
None
 1.08A 4m2xE-3eprA:
3.6		 4m2xE-3eprA:
21.69