SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		5 / 9 PHE A  51
THR A  41
LEU A 238
VAL A 235
GLY A 236
 None
 1.39A 1dz8A-3eq1A:
undetectable		 1dz8A-3eq1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		5 / 9 PHE A  51
THR A  41
LEU A 238
VAL A 235
GLY A 236
 None
 1.37A 1dz8B-3eq1A:
undetectable		 1dz8B-3eq1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		5 / 9 PHE A  51
THR A  41
LEU A 238
VAL A 235
GLY A 236
 None
 1.38A 1dz9B-3eq1A:
undetectable		 1dz9B-3eq1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 VAL A 282
GLY A 281
ALA A 347
LEU A 351
 None
 0.77A 1e7bB-3eq1A:
undetectable		 1e7bB-3eq1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 7 PHE A 158
GLU A 210
GLN A 204
VAL A 123
 None
 1.47A 1jqdA-3eq1A:
undetectable		 1jqdA-3eq1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 LEU A 334
PHE A 253
ALA A 252
LEU A 276
 None
 0.98A 1ukbA-3eq1A:
undetectable		 1ukbA-3eq1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 5 LEU A 137
PHE A 163
VAL A 123
ALA A 185
 None
 1.03A 2cizA-3eq1A:
undetectable		 2cizA-3eq1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 TYR A 213
GLY A 218
ARG A 116
THR A 243
 None
DPM  A 400 (-3.7A)
None
None
 0.93A 2f9wA-3eq1A:
undetectable
2f9wB-3eq1A:
undetectable		 2f9wA-3eq1A:
24.30
2f9wB-3eq1A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 5 LEU A 232
GLN A 314
THR A 319
LEU A  85
 None
 1.13A 3ce6D-3eq1A:
undetectable		 3ce6D-3eq1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		3 / 3 HIS A 207
HIS A 120
ILE A 205
 None
SO4  A 363 (-3.8A)
None
 0.85A 3u52A-3eq1A:
undetectable
3u52C-3eq1A:
undetectable		 3u52A-3eq1A:
21.33
3u52C-3eq1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 GLY A 346
ARG A 156
ILE A 350
LEU A 343
 None
 1.22A 4ac9C-3eq1A:
undetectable		 4ac9C-3eq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 GLY A 346
ARG A 156
ILE A 350
LEU A 343
 None
 1.21A 4acaC-3eq1A:
undetectable		 4acaC-3eq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		6 / 12 THR A 109
GLY A 317
GLN A 332
ILE A 248
GLY A 111
ALA A 320
 None
 1.34A 5kb6A-3eq1A:
undetectable		 5kb6A-3eq1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 4 ASP A 230
ILE A 231
ARG A 225
ARG A  19
 None
 1.29A 5m67C-3eq1A:
0.0		 5m67C-3eq1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 ARG A 156
PHE A 158
ILE A 187
THR A 145
 None
None
None
DPM  A 400 ( 4.8A)
 1.02A 5vceA-3eq1A:
undetectable		 5vceA-3eq1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmA-3eq1A:
undetectable		 5vlmA-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmB-3eq1A:
undetectable		 5vlmB-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		3 / 3 ALA A 219
VAL A 267
TYR A 213
 None
 0.65A 5zmqH-3eq1A:
undetectable		 5zmqH-3eq1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 7 VAL A 316
PRO A 264
LEU A 148
PHE A 253
 None
 1.05A 6aycA-3eq1A:
undetectable		 6aycA-3eq1A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		5 / 9 VAL A 267
HIS A 268
ILE A 350
LEU A 351
ARG A 149
 None
SO4  A 363 (-4.1A)
None
None
DPM  A 400 (-3.6A)
 1.33A 6c2mC-3eq1A:
undetectable		 6c2mC-3eq1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 ILE A 248
GLN A 332
ALA A 297
THR A 298
 None
 0.92A 6cduD-3eq1A:
undetectable
6cduE-3eq1A:
undetectable		 6cduD-3eq1A:
23.28
6cduE-3eq1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 7 ALA A 297
THR A 298
ILE A 248
GLN A 332
 None
 0.93A 6cduF-3eq1A:
undetectable
6cduJ-3eq1A:
undetectable		 6cduF-3eq1A:
23.28
6cduJ-3eq1A:
23.28