SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 6 ILE A  64
HIS A  77
HIS A  75
HIS A 125
 None
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
FE  A 202 (-3.5A)
 0.85A 1y93A-3eqeA:
undetectable		 1y93A-3eqeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 6 ILE A  64
HIS A 125
HIS A  77
HIS A  75
 None
FE  A 202 (-3.5A)
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
 0.95A 1y93A-3eqeA:
undetectable		 1y93A-3eqeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 8 LEU A   3
ILE A  29
ILE A   7
ILE A  10
 None
 0.85A 2bu8A-3eqeA:
undetectable		 2bu8A-3eqeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		5 / 11 HIS A 139
ILE A  64
HIS A  77
HIS A 125
VAL A  74
 None
None
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
None
 1.49A 2zwfA-3eqeA:
undetectable
2zwfB-3eqeA:
undetectable		 2zwfA-3eqeA:
16.90
2zwfB-3eqeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		5 / 12 HIS A 139
THR A  72
LEU A 117
GLY A  82
HIS A  77
 None
None
None
None
FE  A 202 (-3.6A)
 0.96A 3g1uB-3eqeA:
undetectable		 3g1uB-3eqeA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 6 THR A  73
TYR A  48
HIS A 125
HIS A  77
 None
None
FE  A 202 (-3.5A)
FE  A 202 (-3.6A)
 1.49A 4df2A-3eqeA:
undetectable		 4df2A-3eqeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		5 / 12 MET A 127
MET A 148
ILE A  64
ILE A  62
HIS A 139
 FE  A 202 ( 4.8A)
None
None
None
None
 1.18A 4j24B-3eqeA:
undetectable		 4j24B-3eqeA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		5 / 12 ILE A  66
HIS A 139
THR A  72
LEU A  91
LEU A 117
 None
 1.34A 4pbhA-3eqeA:
undetectable		 4pbhA-3eqeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		3 / 3 GLU A  71
TYR A  96
GLU A 153
 None
 0.76A 4ryaA-3eqeA:
undetectable		 4ryaA-3eqeA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		3 / 3 ASP A 147
GLY A  78
ASP A  76
 None
 0.63A 4xdtA-3eqeA:
undetectable		 4xdtA-3eqeA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 5 ILE A  64
HIS A  77
HIS A  75
HIS A 125
 None
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
FE  A 202 (-3.5A)
 0.84A 5n5kA-3eqeA:
undetectable		 5n5kA-3eqeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 5 ILE A  64
HIS A 125
HIS A  77
HIS A  75
 None
FE  A 202 (-3.5A)
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
 0.93A 5n5kA-3eqeA:
undetectable		 5n5kA-3eqeA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		4 / 6 HIS A  77
HIS A  75
LEU A 117
HIS A 139
 FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
None
None
 1.09A 5nelB-3eqeA:
undetectable
5nelC-3eqeA:
undetectable		 5nelB-3eqeA:
20.88
5nelC-3eqeA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3eqe PUTATIVE CYSTEIN
DIOXYGENASE
(Bacillus
subtilis) 		5 / 11 HIS A 139
ILE A  64
HIS A  77
HIS A 125
VAL A  74
 None
None
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
None
 1.46A 5z0mA-3eqeA:
undetectable
5z0mB-3eqeA:
undetectable		 5z0mA-3eqeA:
19.21
5z0mB-3eqeA:
16.37