SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 GLU A  65
LEU A 106
TYR A 102
GLY A 208
GLY A 205
 None
 1.17A 1httC-3eqxA:
undetectable		 1httC-3eqxA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 GLU A  65
LEU A 106
TYR A 102
GLY A 208
GLY A 205
 None
 1.17A 1httD-3eqxA:
undetectable		 1httD-3eqxA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		3 / 3 THR A 143
PRO A 141
PRO A 157
 None
 0.88A 2d55C-3eqxA:
undetectable		 2d55C-3eqxA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 9 GLY A 208
GLU A  73
ASN A 204
ALA A 123
VAL A 120
 None
 1.39A 2drdA-3eqxA:
undetectable		 2drdA-3eqxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 ILE A 296
ALA A 322
LYS A 332
ILE A 305
LEU A 340
 None
 1.28A 2zzaA-3eqxA:
undetectable		 2zzaA-3eqxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 11 ILE A 296
ALA A 322
LYS A 332
ILE A 305
LEU A 340
 None
 1.29A 2zzaB-3eqxA:
undetectable		 2zzaB-3eqxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		3 / 3 PRO A  14
LEU A  12
GLN A 193
 None
 0.60A 3hznG-3eqxA:
undetectable
3hznH-3eqxA:
undetectable		 3hznG-3eqxA:
20.11
3hznH-3eqxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 6 THR A 267
GLN A 266
TYR A 232
ILE A 233
 None
 1.20A 3peoG-3eqxA:
undetectable		 3peoG-3eqxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 6 GLY A 205
THR A 207
LEU A 211
GLU A  73
 None
 1.02A 3ps9A-3eqxA:
undetectable		 3ps9A-3eqxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 MET A 187
LEU A  41
LEU A 227
LEU A 229
ILE A 213
 None
 1.10A 3uvvA-3eqxA:
undetectable		 3uvvA-3eqxA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 6 THR A 248
TYR A 155
HIS A  11
TYR A 192
 PGE  A 373 (-3.3A)
PGE  A 373 ( 3.9A)
None
None
 1.44A 4df2A-3eqxA:
undetectable		 4df2A-3eqxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 LEU A 281
VAL A 339
VAL A 302
TYR A 288
PRO A 354
 None
 1.49A 4ig3A-3eqxA:
undetectable		 4ig3A-3eqxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 10 TYR A 370
VAL A 289
TYR A 288
VAL A 302
LEU A 340
 None
 1.21A 4jq4A-3eqxA:
undetectable		 4jq4A-3eqxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 5 ASN A  53
LEU A  56
LEU A 359
ASN A 365
 None
 1.23A 4n09C-3eqxA:
undetectable		 4n09C-3eqxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 12 ILE A  58
MET A 360
THR A 271
ILE A 275
ILE A 226
 None
 1.05A 4p3qA-3eqxA:
undetectable		 4p3qA-3eqxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 8 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.97A 5dzkd-3eqxA:
undetectable
5dzkr-3eqxA:
undetectable		 5dzkd-3eqxA:
18.85
5dzkr-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 8 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.77A 5dzkF-3eqxA:
undetectable
5dzkT-3eqxA:
undetectable		 5dzkF-3eqxA:
18.85
5dzkT-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 4 CYH A 311
LEU A 316
LEU A 331
ALA A 327
 None
 1.11A 5hpuA-3eqxA:
undetectable
5hpuB-3eqxA:
undetectable		 5hpuA-3eqxA:
6.33
5hpuB-3eqxA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		5 / 9 LEU A 124
ARG A 138
ILE A 197
GLU A 195
GLU A 172
 None
 1.48A 5igzA-3eqxA:
undetectable		 5igzA-3eqxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 4 ASP A 182
ILE A  30
PRO A  29
LEU A  31
 None
 1.25A 6mkeB-3eqxA:
undetectable		 6mkeB-3eqxA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 4 ASP A 182
ILE A  30
PRO A  29
LEU A  31
 None
 1.30A 6mkeA-3eqxA:
undetectable		 6mkeA-3eqxA:
11.57