SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.87A 1drbB-3eqzA:
undetectable		 1drbB-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 8 GLU A 112
ILE A  21
THR A  20
LEU A  17
 GLU  A 112 ( 0.6A)
ILE  A  21 ( 0.7A)
THR  A  20 ( 0.8A)
LEU  A  17 ( 0.5A)
 0.79A 1hmyA-3eqzA:
5.7		 1hmyA-3eqzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.87A 1ra2A-3eqzA:
undetectable		 1ra2A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.88A 1ra8A-3eqzA:
undetectable		 1ra8A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.87A 1rb2A-3eqzA:
undetectable		 1rb2A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.90A 1rd7A-3eqzA:
undetectable		 1rd7A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.92A 1rx2A-3eqzA:
undetectable		 1rx2A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.95A 2d0kB-3eqzA:
undetectable		 2d0kB-3eqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		3 / 3 ASP A  57
THR A  40
GLU A  62
 ASP  A  57 ( 0.5A)
THR  A  40 ( 0.8A)
GLU  A  62 ( 0.6A)
 0.81A 2zifB-3eqzA:
2.5		 2zifB-3eqzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 ASP A  52
SER A  80
GLY A  81
ASP A  11
 ASP  A  52 ( 0.6A)
SER  A  80 ( 0.0A)
GLY  A  81 ( 0.0A)
ASP  A  11 ( 0.5A)
 1.26A 3w9tB-3eqzA:
undetectable		 3w9tB-3eqzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 ASP A  52
SER A  80
GLY A  81
ASP A  11
 ASP  A  52 ( 0.6A)
SER  A  80 ( 0.0A)
GLY  A  81 ( 0.0A)
ASP  A  11 ( 0.5A)
 1.26A 3w9tC-3eqzA:
undetectable		 3w9tC-3eqzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.82A 4ej1A-3eqzA:
undetectable		 4ej1A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.84A 4fhbA-3eqzA:
undetectable		 4fhbA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.93A 4i13A-3eqzA:
undetectable		 4i13A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.88A 4nx6A-3eqzA:
undetectable		 4nx6A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.86A 4nx7A-3eqzA:
undetectable		 4nx7A-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.84A 4p3rA-3eqzA:
undetectable		 4p3rA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.89A 4pssA-3eqzA:
undetectable		 4pssA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.96A 4pstA-3eqzA:
undetectable		 4pstA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A  67
ILE A  61
ILE A  79
VAL A  63
ILE A  64
 LEU  A  67 ( 0.6A)
ILE  A  61 ( 0.7A)
ILE  A  79 ( 0.7A)
VAL  A  63 ( 0.6A)
ILE  A  64 ( 0.6A)
 1.05A 4q1yB-3eqzA:
undetectable		 4q1yB-3eqzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.82A 4x5iA-3eqzA:
undetectable		 4x5iA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.88A 5eajA-3eqzA:
undetectable		 5eajA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 6 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.93A 5gs4A-3eqzA:
undetectable		 5gs4A-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.91A 5gtrA-3eqzA:
undetectable		 5gtrA-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 7 LEU A  41
SER A  72
ILE A  77
ASP A  47
 LEU  A  41 ( 0.6A)
SER  A  72 ( 0.0A)
ILE  A  77 ( 0.7A)
ASP  A  47 ( 0.6A)
 0.94A 5n5dA-3eqzA:
3.2		 5n5dA-3eqzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.90A 5ujxA-3eqzA:
undetectable		 5ujxA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 7 PHE A  38
VAL A  63
ILE A  77
SER A  72
 PHE  A  38 ( 1.3A)
VAL  A  63 ( 0.6A)
ILE  A  77 ( 0.7A)
SER  A  72 ( 0.0A)
 1.02A 5vkqA-3eqzA:
undetectable
5vkqD-3eqzA:
undetectable		 5vkqA-3eqzA:
5.66
5vkqD-3eqzA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 8 SER A 120
PHE A  26
VAL A 113
ILE A  50
 SER  A 120 ( 0.0A)
PHE  A  26 ( 1.3A)
VAL  A 113 ( 0.6A)
ILE  A  50 ( 0.7A)
 1.11A 5vkqB-3eqzA:
undetectable
5vkqC-3eqzA:
undetectable		 5vkqB-3eqzA:
5.66
5vkqC-3eqzA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.90A 5z6jA-3eqzA:
undetectable		 5z6jA-3eqzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		5 / 12 LEU A 114
PHE A 117
ILE A  48
LEU A 121
ILE A 102
 LEU  A 114 ( 0.6A)
PHE  A 117 ( 1.3A)
ILE  A  48 ( 0.7A)
LEU  A 121 ( 0.6A)
ILE  A 102 ( 0.7A)
 0.90A 5z6kA-3eqzA:
undetectable		 5z6kA-3eqzA:
17.88