SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ers'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA502_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	3ers	TRNA-BINDING PROTEIN YGJH (Escherichia coli)	4 / 8	THR X 47 LEU X 83 VAL X 36 VAL X 34	None	0.97A	4em2A-3ersX: undetectable	4em2A-3ersX: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PO0_A_NPSA601_1 (SERUM ALBUMIN)	3ers	TRNA-BINDING PROTEIN YGJH (Escherichia coli)	5 / 12	VAL X 65 CYH X 81 LEU X 49 TYR X 53 VAL X 36	None	1.40A	4po0A-3ersX: undetectable	4po0A-3ersX: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ICX_F_SC2F1_1 (CETUXIMAB FAB LIGHT CHAIN MEDITOPE)	3ers	TRNA-BINDING PROTEIN YGJH (Escherichia coli)	3 / 3	VAL X 38 GLN X 44 CYH X 81	None	0.91A	5icxC-3ersX: undetectable 5icxF-3ersX: undetectable	5icxC-3ersX: 18.22 5icxF-3ersX: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_D_SUED1202_1 (NS3 PROTEASE)	3ers	TRNA-BINDING PROTEIN YGJH (Escherichia coli)	4 / 9	VAL X 109 LEU X 83 VAL X 95 SER X 94	None	0.85A	6c2mD-3ersX: undetectable	6c2mD-3ersX: 23.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4EM2_A_SALA502_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","3ers","TRNA-BINDING PROTEIN YGJH","Escherichia coli",4,"THR X  47;LEU X  83;VAL X  36;VAL X  34","None","0.97A","4em2A-3ersX:undetectable","4em2A-3ersX:19.67"],["4PO0_A_NPSA601_1","SERUM ALBUMIN","3ers","TRNA-BINDING PROTEIN YGJH","Escherichia coli",5,"VAL X  65;CYH X  81;LEU X  49;TYR X  53;VAL X  36","None","1.40A","4po0A-3ersX:undetectable","4po0A-3ersX:12.62"],["5ICX_F_SC2F1_1","CETUXIMAB FAB LIGHT CHAIN;MEDITOPE","3ers","TRNA-BINDING PROTEIN YGJH","Escherichia coli",3,"VAL X  38;GLN X  44;CYH X  81","None","0.91A","5icxC-3ersX:undetectable;5icxF-3ersX:undetectable","5icxC-3ersX:18.22;5icxF-3ersX:9.68"],["6C2M_D_SUED1202_1","NS3 PROTEASE","3ers","TRNA-BINDING PROTEIN YGJH","Escherichia coli",4,"VAL X 109;LEU X  83;VAL X  95;SER X  94","None","0.85A","6c2mD-3ersX:undetectable","6c2mD-3ersX:23.89"]]