SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3es1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.33A 1mj2B-3es1A:
undetectable		 1mj2B-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.29A 1mj2D-3es1A:
undetectable		 1mj2D-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.32A 1mjoB-3es1A:
undetectable		 1mjoB-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.33A 1mjoA-3es1A:
undetectable		 1mjoA-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.31A 1mjoD-3es1A:
undetectable		 1mjoD-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 SER A   8
ARG A 145
LEU A   5
SER A   6
 None
 0.97A 2qhfA-3es1A:
0.0		 2qhfA-3es1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 PRO A  35
THR A  36
LEU A  10
 None
 0.79A 3ttrA-3es1A:
undetectable		 3ttrA-3es1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ARG A  81
ASP A 100
GLY A 102
VAL A 121
LEU A 111
 None
 1.09A 4y8wA-3es1A:
undetectable		 4y8wA-3es1A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ARG A  81
ASP A 100
GLY A 102
VAL A 121
LEU A 111
 None
 1.05A 4y8wB-3es1A:
undetectable		 4y8wB-3es1A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 136
MET A  85
ASN A 138
 None
 1.40A 5uc1B-3es1A:
undetectable		 5uc1B-3es1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 136
MET A  85
ASN A 138
 None
 1.40A 5uc1A-3es1A:
undetectable		 5uc1A-3es1A:
18.82