SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3es5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 8 GLU A 132
LEU A 139
ALA A 121
THR A 183
 None
 0.80A 1ie4B-3es5A:
undetectable
1ie4D-3es5A:
undetectable		 1ie4B-3es5A:
15.48
1ie4D-3es5A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 12 GLN A 356
VAL A 358
GLY A 354
GLY A 168
VAL A  73
 None
 1.10A 1jg4A-3es5A:
undetectable		 1jg4A-3es5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		6 / 12 LEU A 272
LEU A 275
LEU A 300
LEU A 250
LEU A 255
TYR A 258
 None
 1.06A 1sqnB-3es5A:
undetectable		 1sqnB-3es5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		3 / 3 ASP A 237
VAL A 245
PRO A 248
 None
 0.67A 2avvA-3es5A:
undetectable		 2avvA-3es5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 5 LEU A 301
ILE A 217
LEU A 214
SER A 213
 None
 0.82A 2byoA-3es5A:
undetectable		 2byoA-3es5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 6 SER A 360
VAL A 358
THR A  82
PRO A 384
 None
 1.16A 2hdnJ-3es5A:
undetectable
2hdnK-3es5A:
undetectable
2hdnL-3es5A:
undetectable		 2hdnJ-3es5A:
19.55
2hdnK-3es5A:
8.84
2hdnL-3es5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 5 PHE A  77
PHE A 118
SER A 111
ILE A 193
 None
 1.32A 2v0mD-3es5A:
2.0		 2v0mD-3es5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 12 LEU A 272
LEU A 275
LEU A 300
LEU A 250
TYR A 258
 None
 1.14A 3d90A-3es5A:
undetectable		 3d90A-3es5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 12 LEU A 272
LEU A 275
LEU A 300
LEU A 250
TYR A 258
 None
 1.08A 3d90B-3es5A:
undetectable		 3d90B-3es5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 8 ALA A 121
VAL A 142
GLY A 182
GLY A 186
 None
 0.61A 4zjzA-3es5A:
undetectable		 4zjzA-3es5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 7 SER A 360
ALA A 365
PRO A 384
LEU A 381
 None
 1.13A 5dzkD-3es5A:
undetectable
5dzkR-3es5A:
undetectable		 5dzkD-3es5A:
19.14
5dzkR-3es5A:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		6 / 12 GLY A 352
VAL A 170
VAL A 172
PHE A 388
ILE A 376
VAL A 358
 None
 1.46A 5n0tA-3es5A:
undetectable		 5n0tA-3es5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		4 / 7 ARG A  97
GLN A  99
ILE A  98
GLY A  95
 None
 0.92A 5nzyA-3es5A:
undetectable		 5nzyA-3es5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 12 ASP A 145
ILE A 315
ALA A 312
THR A 198
GLU A 323
 None
 1.21A 5vcgA-3es5A:
undetectable		 5vcgA-3es5A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 12 ILE A  83
GLY A 379
ALA A 355
ILE A 160
LEU A  75
 None
 1.12A 6dwnD-3es5A:
undetectable		 6dwnD-3es5A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3es5 PUTATIVE CAPSID
PROTEIN
(Penicillium
stoloniferum
virus
F) 		5 / 10 PHE A 117
ALA A 121
TYR A 125
TYR A 143
PHE A 179
 None
 1.42A 6hu9C-3es5A:
1.6		 6hu9C-3es5A:
21.17