SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3esf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 6 TRP A 163
GLY A 146
ASN A  68
PRO A 148
 None
 1.24A 1dedA-3esfA:
undetectable		 1dedA-3esfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 7 TYR A  29
HIS A  76
HIS A  32
TYR A  36
 None
FE  A 198 (-3.3A)
None
None
 1.29A 2ombC-3esfA:
undetectable
2ombD-3esfA:
undetectable		 2ombC-3esfA:
23.01
2ombD-3esfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 7 TRP A 127
GLN A 194
PHE A  78
PHE A  74
 None
 1.04A 2qmzA-3esfA:
undetectable
2qmzB-3esfA:
undetectable		 2qmzA-3esfA:
20.50
2qmzB-3esfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 5 GLN A 194
PHE A  78
PHE A  74
TRP A 127
 None
 1.03A 2qmzA-3esfA:
undetectable
2qmzB-3esfA:
undetectable		 2qmzA-3esfA:
20.50
2qmzB-3esfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 7 TRP A 127
GLN A 194
PHE A  78
PHE A  74
 None
 0.96A 2qwxA-3esfA:
undetectable
2qwxB-3esfA:
undetectable		 2qwxA-3esfA:
21.25
2qwxB-3esfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 7 TRP A 127
GLN A 194
PHE A  78
PHE A  74
 None
 0.97A 2qx4A-3esfA:
undetectable
2qx4B-3esfA:
undetectable		 2qx4A-3esfA:
20.50
2qx4B-3esfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 6 TYR A 178
HIS A  28
HIS A  76
TYR A  79
 None
FE  A 198 (-3.4A)
FE  A 198 (-3.3A)
None
 1.45A 4df2A-3esfA:
undetectable		 4df2A-3esfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 8 GLN A 194
PHE A  78
PHE A  74
TRP A 127
 None
 0.94A 4fgjA-3esfA:
undetectable
4fgjB-3esfA:
undetectable		 4fgjA-3esfA:
21.07
4fgjB-3esfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		5 / 11 ILE A 157
ALA A 191
GLU A  81
GLY A  87
TRP A 188
 None
 1.41A 4j83A-3esfA:
undetectable		 4j83A-3esfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2
(Trypanosoma
brucei) 		4 / 6 TRP A 127
GLN A 194
PHE A  78
PHE A  74
 None
 0.95A 4qogA-3esfA:
undetectable
4qogB-3esfA:
undetectable		 4qogA-3esfA:
21.25
4qogB-3esfA:
21.25