SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3esh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 VAL A  27
VAL A 219
TRP A  32
 None
 0.74A 1bdwA-3eshA:
undetectable
1bdwB-3eshA:
undetectable		 1bdwA-3eshA:
3.65
1bdwB-3eshA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 ASP A  63
THR A 107
HIS A 108
ILE A 207
 None
 1.00A 1ei6C-3eshA:
undetectable		 1ei6C-3eshA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 THR A  16
ASP A 112
GLY A  65
ILE A  51
ALA A 257
 None
 1.38A 1oltA-3eshA:
undetectable		 1oltA-3eshA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 11 ASP A 112
HIS A 113
HIS A 185
ASP A 206
HIS A 251
 None
 0.40A 2q0jB-3eshA:
11.8		 2q0jB-3eshA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 LEU A 272
ASP A 268
VAL A 258
THR A 211
 None
 1.26A 3cyxB-3eshA:
undetectable		 3cyxB-3eshA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ILE A  51
ILE A  61
ILE A 192
HIS A 113
HIS A 108
 None
 1.24A 3o1cA-3eshA:
undetectable		 3o1cA-3eshA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ILE A  51
ILE A  61
ILE A 192
HIS A 113
HIS A 108
 None
 1.24A 3o1xA-3eshA:
undetectable		 3o1xA-3eshA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ILE A  51
ILE A  61
ILE A 192
HIS A 113
HIS A 108
 None
 1.24A 3qgzA-3eshA:
undetectable		 3qgzA-3eshA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 LEU A  11
ALA A  64
PHE A 126
ASN A  68
 None
 1.28A 3uq6A-3eshA:
undetectable		 3uq6A-3eshA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 LEU A  11
ALA A  64
PHE A 126
ASN A  68
 None
 1.29A 3vaqA-3eshA:
undetectable		 3vaqA-3eshA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 LEU A  11
ALA A  64
PHE A 126
ASN A  68
 None
 1.25A 3vasA-3eshA:
undetectable		 3vasA-3eshA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLU A 140
ASP A 224
SER A 182
GLU A 137
TYR A 152
 None
 1.48A 4b7qB-3eshA:
undetectable		 4b7qB-3eshA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 HIS A 108
HIS A 110
ASP A 112
HIS A 185
HIS A 251
 None
 0.94A 4c1dB-3eshA:
14.6		 4c1dB-3eshA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 11 HIS A 108
HIS A 110
ASP A 112
HIS A 185
HIS A 251
 None
 0.99A 4c1fA-3eshA:
15.7
4c1fB-3eshA:
15.8		 4c1fA-3eshA:
21.84
4c1fB-3eshA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 9 HIS A 108
HIS A 110
ASP A 112
HIS A 185
HIS A 251
 None
 0.95A 4c1hA-3eshA:
2.7		 4c1hA-3eshA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 THR A  16
GLN A  43
THR A 210
HIS A 213
 None
 1.25A 4pfjB-3eshA:
undetectable		 4pfjB-3eshA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 ARG A 273
VAL A  81
GLY A  67
GLY A  65
ILE A  66
 None
 0.79A 4q5mA-3eshA:
undetectable		 4q5mA-3eshA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 PHE A 240
TYR A 260
PHE A 247
PHE A 249
 None
 0.99A 4qoiA-3eshA:
undetectable
4qoiB-3eshA:
undetectable		 4qoiA-3eshA:
20.00
4qoiB-3eshA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 126
GLY A  69
LEU A  71
VAL A  81
THR A  16
 None
 1.13A 4wnwA-3eshA:
undetectable		 4wnwA-3eshA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		6 / 11 HIS A 108
HIS A 110
ASP A 112
HIS A 113
HIS A 185
HIS A 251
 None
 0.53A 5ayaA-3eshA:
14.6		 5ayaA-3eshA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 11 HIS A 110
ASP A 112
HIS A 113
THR A 220
HIS A 251
 None
 1.08A 5ayaA-3eshA:
14.6		 5ayaA-3eshA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 ASP A 112
GLU A 140
ASP A 224
TYR A 225
 None
 0.97A 5cfsA-3eshA:
undetectable		 5cfsA-3eshA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 8 GLU A 137
HIS A 189
GLY A 183
HIS A 108
ASP A 206
 None
 1.49A 5f8yA-3eshA:
undetectable		 5f8yA-3eshA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 8 GLU A 137
HIS A 189
GLY A 184
HIS A 108
ASP A 206
 None
 1.15A 5f8yA-3eshA:
undetectable		 5f8yA-3eshA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 8 GLU A 137
HIS A 189
GLY A 184
HIS A 108
ASP A 206
 None
 1.18A 5f8yB-3eshA:
undetectable		 5f8yB-3eshA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 ILE A  87
GLY A  13
THR A  48
ALA A  64
VAL A 104
 None
 1.24A 5hw4C-3eshA:
undetectable		 5hw4C-3eshA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 HIS A 108
HIS A 110
HIS A 113
HIS A 185
ASP A 206
 None
 0.46A 5nzwA-3eshA:
5.8		 5nzwA-3eshA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 MET A  23
ASP A 206
ARG A 273
 None
 1.08A 5z6jA-3eshA:
undetectable		 5z6jA-3eshA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 MET A  23
ASP A 206
ARG A 273
 None
 1.15A 5z6kA-3eshA:
undetectable		 5z6kA-3eshA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 HIS A 110
ASP A 112
HIS A 185
HIS A 251
 None
 1.04A 5zj8A-3eshA:
12.6		 5zj8A-3eshA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 THR A  16
HIS A 251
ASP A 206
HIS A 113
 None
 1.31A 6dchA-3eshA:
undetectable		 6dchA-3eshA:
20.29