SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3esl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 190
SER A 143
ASN A 172
SER A 150
 None
 1.46A 1kiaB-3eslA:
undetectable		 1kiaB-3eslA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 190
SER A 143
ASN A 172
SER A 150
 None
 1.45A 1kiaC-3eslA:
undetectable		 1kiaC-3eslA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  92
THR A 218
TYR A 132
TYR A 114
 None
 1.40A 1qvuA-3eslA:
undetectable		 1qvuA-3eslA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 198
LEU A 160
LEU A 168
 None
 0.69A 3ohtA-3eslA:
undetectable		 3ohtA-3eslA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 198
LEU A 160
LEU A 168
 None
 0.69A 3ohtB-3eslA:
undetectable		 3ohtB-3eslA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 142
ARG A 179
LEU A 108
PRO A 105
 None
 0.95A 3onnA-3eslA:
undetectable		 3onnA-3eslA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 121
LEU A 152
PHE A 118
 None
 0.81A 4dajB-3eslA:
undetectable		 4dajB-3eslA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 103
LEU A 214
GLY A 169
SER A 143
ARG A 179
 None
 1.39A 4djeA-3eslA:
undetectable		 4djeA-3eslA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 188
LEU A 191
LYS A 163
LEU A 166
 None
 1.13A 5yvnA-3eslA:
undetectable		 5yvnA-3eslA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  41
THR A  87
ARG A  90
SER A  79
 None
 0.97A 6c06C-3eslA:
undetectable		 6c06C-3eslA:
undetectable