SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3et5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		3 / 4 VAL A  95
TRP A  78
TRP A  91
 None
 1.08A 1gmkA-3et5A:
undetectable
1gmkB-3et5A:
undetectable		 1gmkA-3et5A:
4.33
1gmkB-3et5A:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 11 GLY A  31
SER A  30
ALA A  35
ALA A  37
TRP A  26
 None
 1.09A 1ukbA-3et5A:
undetectable		 1ukbA-3et5A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 8 TYR A 178
GLU A 169
PHE A 213
ILE A 214
 None
 1.08A 3jz0B-3et5A:
undetectable		 3jz0B-3et5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 GLY A 118
ASN A 114
ALA A  47
THR A 212
LEU A 177
 None
 1.05A 3p2kB-3et5A:
undetectable		 3p2kB-3et5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 5 ASP A 181
ASP A 138
ASN A  72
GLU A  67
 MG  A 255 (-2.6A)
None
None
PG4  A 257 (-3.4A)
 1.40A 3vywD-3et5A:
2.8		 3vywD-3et5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ILE A 214
PHE A 213
LEU A 177
VAL A  61
ILE A 168
 None
 1.03A 4g1bD-3et5A:
3.4		 4g1bD-3et5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		4 / 6 ASP A  64
ALA A 160
TYR A 191
ASP A 185
 MG  A 255 ( 2.5A)
None
None
MG  A 255 ( 4.2A)
 1.20A 4mdbA-3et5A:
undetectable		 4mdbA-3et5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ASP A  64
THR A 124
THR A 135
VAL A 103
ASP A 181
 MG  A 255 ( 2.5A)
WO4  A 256 (-3.6A)
None
None
MG  A 255 (-2.6A)
 1.11A 4njgA-3et5A:
0.2		 4njgA-3et5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ASP A  64
THR A 124
THR A 135
VAL A 103
ASP A 181
 MG  A 255 ( 2.5A)
WO4  A 256 (-3.6A)
None
None
MG  A 255 (-2.6A)
 1.12A 4njgB-3et5A:
0.2		 4njgB-3et5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ASP A  64
THR A 124
THR A 135
VAL A 103
ASP A 181
 MG  A 255 ( 2.5A)
WO4  A 256 (-3.6A)
None
None
MG  A 255 (-2.6A)
 1.33A 4njiA-3et5A:
0.0		 4njiA-3et5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ASP A  64
THR A 124
THR A 135
VAL A 103
ASP A 181
 MG  A 255 ( 2.5A)
WO4  A 256 (-3.6A)
None
None
MG  A 255 (-2.6A)
 1.31A 4njiB-3et5A:
0.1		 4njiB-3et5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 ASP A  64
THR A 124
THR A 135
VAL A 103
ASP A 181
 MG  A 255 ( 2.5A)
WO4  A 256 (-3.6A)
None
None
MG  A 255 (-2.6A)
 1.29A 4njjA-3et5A:
0.0		 4njjA-3et5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		3 / 3 ASP A 185
ASP A 181
ASN A  72
 MG  A 255 ( 4.2A)
MG  A 255 (-2.6A)
None
 0.73A 4q5mA-3et5A:
undetectable		 4q5mA-3et5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.95A 4rrwA-3et5A:
undetectable		 4rrwA-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.98A 4rrwB-3et5A:
undetectable		 4rrwB-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.97A 4rrwC-3et5A:
undetectable		 4rrwC-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.95A 4rrzA-3et5A:
undetectable		 4rrzA-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.98A 4rrzB-3et5A:
undetectable		 4rrzB-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 VAL A 179
LEU A 216
VAL A 103
GLY A 105
ALA A 106
 None
 0.97A 4rrzC-3et5A:
undetectable		 4rrzC-3et5A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE
(Haemophilus
influenzae) 		5 / 12 GLY A  77
ASN A  82
SER A  73
ASP A  66
ARG A 126
 None
None
PG4  A 257 (-4.9A)
WO4  A 256 ( 3.7A)
None
 1.09A 5hikA-3et5A:
2.9		 5hikA-3et5A:
21.43